Resumen
A common side effect of radiotherapy is the impairment of integrity and functionality of the co-irradiated surrounding normal tissue. Homeostasis and regeneration of many organs are maintained by specific stem/progenitor cells. Radiation can harm these resident stem/progenitor populations involving the disruption of the signaling cascade of pathways known to normally sustain stem/progenitor cellular activity. This review describes the currently existing models used to study the response of stem/progenitor cells to irradiation and the key signaling pathways involved during solid tissue-specific stem/progenitor driven regeneration.