Inicio  /  Cancers  /  Vol: 13 Par: 19 (2021)  /  Artículo
ARTÍCULO
TITULO

Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis

Saima Usman    
Naushin H. Waseem    
Thuan Khanh Ngoc Nguyen    
Sahar Mohsin    
Ahmad Jamal    
Muy-Teck Teh and Ahmad Waseem    

Resumen

Vimentin is an important filamentous protein providing structural and functional support to the cell. During initial stages of cancer development, vimentin concentration is very low, however, it increases when cancer starts to invade the surrounding areas. This review highlights the varied roles of vimentin in cancer growth and its spread to distant areas of the body. We have tried to explore the potential new areas of research related to the role of vimentin in cancer progression. We have also highlighted the reported damage to the vimentin gene in cancers, although how the damaged vimentin helps in cancer growth and spread is not known. We propose that latest technologies should be employed to medicinally target vimentin to reduce the cancer growth and its spread thereby helping to increase treatment outcomes and patients? survival.

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