Resumen
Luteolin is a natural compound from plants with various medicinal benefits, including anti-cancer activities. However, luteolin has limited use clinically due to its low solubility and absorption into the body. Hence, the objective of this research work was to formulate and optimize a luteolin nanomicelle formulation with improved solubility. The nanomicelle was prepared using D-a-tocopheryl polyethylene glycol 100 succinate (TPGS) and poloxamer (Pol). The solubility of Lut-loaded micelles increased up to 459-fold compared to pure Lut in water. The release study showed that Lut-loaded micelles exhibited sustained release behavior. The effects of copolymers, hydration temperature and duration, and freezing temperature were studied to find out the optimum formulation of a luteolin?micelle complex. This study has demonstrated that several factors need to be considered when developing such nanoparticles in order to obtain a well-optimized micelle. The formulation has potential to be utilized in cancer therapy.