Resumen
Non-muscle invasive bladder cancer (NMIBC) accounts for three quarters of newly detected bladder tumors. NMIBC can be treated conservatively with a bladder transurethral resection (bTUR), although recurrences are common despite adjuvant treatments. High-risk recurrent NMIBC can progress to muscle invasive bladder cancer (MIBC) and decrease survival. Therefore, close invasive surveillance, based on cystoscopy and washing cytology, is currently recommended, especially in high-risk recurrent tumors. Urine biomarkers have been investigated unsuccessfully to avoid or postpone the invasive surveillance of NMIBC. Xpert Bladder Cancer Monitor® (XBM) is a new genetic urine biomarker that assesses the expression of five miRNA profiles. In the present study, XBM was not sensitive enough to detect all high-risk recurrences and avoid cystoscopy and washing cytology. However, false positive XBM results can predict early high-risk recurrences.