Resumen
Hepatocellular carcinoma (HCC) is a malignant tumor with a high incidence rate and the fourth leading cause of death in cancer patients. YEATS domain containing 2 (YEATS2) gene encodes a scaffolding subunit of the ATAC complex. We found that YEATS2 was upregulated in HCC tissues and was associated with poorer prognosis of patients. We found that overexpression of YEATS2 promoted the process of tumor proliferation, migration, and invasion. Mechanistically, we revealed that YEATS2 promoted liver cancer progression by activating the PI3K/AKT signaling pathway and remodeling the extracellular matrix. Therefore, these findings suggest that YEATS2 holds promise as a new therapeutic target.