Resumen
Novel therapeutic agents have been identified in the management of cervical, endometrial, and ovarian cancer. Immune checkpoint inhibitors improve anti-tumor immunity and have shown clinical efficacy in the management of advanced or metastatic cervical and endometrial cancers. Antibody?drug conjugates couple a potent cytotoxic agent to a highly specific monoclonal antibody to achieve cancer-specific targeted therapy and have proven efficacious in advanced or recurrent cervical, endometrial, and ovarian cancers. The aim of this article is to review recent advances in the targeted treatment of gynecologic malignancies and to review the trials and data underlying the Food and Drug Administration (FDA) approval and National Comprehensive Cancer Network (NCCN) recommendation of these therapeutic agents.