Resumen
Clear cell renal cell carcinomas (CCRCCs) evolve as dynamic communities of individuals (cells) that are amenable to being studied under sociological rules. Here, the early period of development in CCRCC, progressing from initial homogeneity to high intratumor heterogeneity (ITH) and secondary clonal and sub-clonal diversification, is considered using the hawk-dove game. Fitness is a measure of biological aggressiveness in tumors. The results demonstrate that the fittest clone of a neoplasm in a heterogeneous context is fitter than the clone in a homogeneous environment in the early phases of tumor evolution. This study notes the advantages of a translational multidisciplinary approach in cancer research.