Resumen
The definition of tumor hypoxia is important in oncology because this characteristic is linked to a poor prognosis but remains debated because there are no reference modalities. In this context, we compared PET hypoxia (FMISO) and MRI data before surgery to determine the hypoxic volume at which to increase the radiotherapy dose in head and neck cancers. To our knowledge, this is the first study showing the value of combining tumor volumes obtained via PET and MRI to define the hypoxic lesion subvolume. The quantitative MRI parameters ADC, T1 mapping, and T2 mapping showed differences between hypoxic and normoxic volumes.