Resumen
Increasing evidence suggests that bacterial infection not only promotes carcinogenesis in primary colorectal cancer, but also affects metastatic progression and organ selectivity through modification of the microenvironment at primary and secondary tumor sites. The metastatic cascade is the process by which neoplastic tumors potentiate cancerous spread to distant organs, and evidence suggests that this process is provoked in the setting of bacterial infection. Biofilm formation, paired migration, and quorum sensing are processes by which bacteria self-signal, recruit, and effectively establish a pre-metastatic niche at distant sites, rendering a suitable environment for tumor cell survival and proliferation.