Resumen
Cancer treatments have made remarkable advances with the introduction of immunotherapy, which recruits the body?s immune system to fight cancer. Despite these advancements, cancer can sometimes develop resistance to such treatments, diminishing their effectiveness. Our research is focused on the early detection of signs that indicate a cancer?s resistance to immunotherapy, enabling physicians to swiftly alter treatment approaches and improve the chances of patient recovery. We are particularly keen on identifying distinct markers in tumors that indicate this resistance. To achieve a deeper understanding, we utilized scaled-down models of patient tumors, including organoids and xenografts, in laboratory studies. Our goal was to discover innovative methods to combat treatment resistance, potentially enhancing patient care and providing valuable insights for ongoing cancer research.