Inicio  /  Cancers  /  Vol: 16 Par: 1 (2024)  /  Artículo
ARTÍCULO
TITULO

Dysregulation of Peripheral Blood Mononuclear Cells and Immune-Related Proteins during the Early Post-Operative Immune Response in Ovarian Cancer Patients

Jonas Ulevicius    
Aldona Jasukaitiene    
Arenida Bartkeviciene    
Zilvinas Dambrauskas    
Antanas Gulbinas    
Daiva Urboniene and Saulius Paskauskas    

Resumen

This study investigated the immune response in ovarian cancer (OC) patients before and after surgery. The aim was to explore how the immune system is affected by surgery, with a specific focus on peripheral blood mononuclear cells (PBMCs). An analysis of blood samples revealed pre-operative immune imbalances in OC patients that were further exacerbated post-operatively. The study results suggest that OC patients experience a degree of immune suppression, particularly during the early post-operative period. This indicates a potential window of vulnerability that could facilitate cancer progression. Our findings may contribute to the development of better treatment strategies and improved outcomes for OC patients.

Palabras claves

ovarian cancer -  surgery -  PBMC -  IL-1ß -  IL-4 -  IL-6 -  IL-10 -  PD-1 -  PD-L1 -  HO-1
PÁGINAS
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