Resumen
Women at high risk for breast cancer are regularly screened using contrast-enhanced magnetic resonance imaging (MRI) to identify potential malignancy. Diffusion-weighted MRI (DW-MRI) is a non-contrast technique that measures the differential movement of water molecules in tissues and is sensitive to cancer cells. In this study, we use a multi-exponential advanced DW-MRI model called restriction spectrum imaging (RSI) to characterize the diffusion characteristics of malignant lesions, benign lesions, and healthy breast tissue to help differentiate benign from malignant disease. In a cohort of patients, we show that cancer exhibits more restricted diffusion compared to benign breast lesions and healthy tissue, whereas benign and healthy tissue are not different from each other.