Inicio  /  Cancers  /  Vol: 13 Par: 22 (2021)  /  Artículo
ARTÍCULO
TITULO

Identification of a Distinct miRNA Regulatory Network in the Tumor Microenvironment of Transformed Mycosis Fungoides

Cosimo Di Raimondo    
Zhen Han    
Chingyu Su    
Xiwei Wu    
Hanjun Qin    
James F. Sanchez    
Yate-Ching Yuan    
Xochiquetzal Martinez    
Farah Abdulla    
Jasmine Zain    
Chun-Wei Chen    
Steven T. Rosen and Christiane Querfeld    

Resumen

Transformed mycosis fungoides (LCT-MF) is a histopathological marker of poor prognosis and associated with worse survival. We compared miRNA and mRNA expression profiles of LCT-MF with classic MF and found a distinct miRNA regulatory network modulated immunosuppressive tumor microenvironment in LCT-MF. Our findings provide novel insights and therapeutic targets for LCT-MF.

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