Resumen
Limited studies have focused specifically on early-stage NSCLC patients, although there is a particular clinical need for risk stratification in these patients because there are very few therapeutic options in the adjuvant setting. In this prospective study, we compared ddPCR data of hotspot mutations for four therapeutically relevant genes (BRAF, EGFR, KRAS, PIK3CA) from three different patient-matched sample types (FFPE, CTC-derived DNA and plasma-ctDNA) from early-stage NSCLC patients before surgery. We demonstrated that simultaneous analyses of plasma-cfDNA and CTC-derived DNA provided complementary molecular information from the same blood sample and greater diversity in genomic information for cancer treatment and prognosis.