Resumen
The clinical management of locally advanced rectal cancer (LARC) patients would benefit for the establishment of molecular markers that could anticipate the response to neoadjuvant chemoradiotherapy (CRT). We aimed here to validate in an independent cohort our previous findings about the prognostic value showed by miR-199b in LARC as well as to explore its status in the disease progression. Notably, we confirmed in this work that miR-199b has a predictive value of both outcome and response to preoperative CRT in LARC patients further strengthen its potential usefulness in this disease.