Resumen
Polymerase delta 1 (POLD1), a catalytic and proofreading subunit of the human DNA polymerase delta (Pold), plays a vital role in maintaining the stability of the genome. In recent years, POLD1 germline and somatic mutations, as well as gene-expression patterns, have been extensively studied in cancers. Nevertheless, the complex regulatory mechanisms of POLD1 expression and their clinical relevance are yet to be elucidated. This review aims to summarize the current research status regarding the role of POLD1 in neoplastic processes.