Inicio  /  Cancers  /  Vol: 13 Par: 22 (2021)  /  Artículo
ARTÍCULO
TITULO

Clinicopathological Determinants of Recurrence Risk and Survival in Mucinous Ovarian Carcinoma

Robert L. Hollis    
Lorna J. Stillie    
Samantha Hopkins    
Clare Bartos    
Michael Churchman    
Tzyvia Rye    
Fiona Nussey    
Scott Fegan    
Rachel Nirsimloo    
Gareth J. Inman    
C. Simon Herrington and Charlie Gourley    

Resumen

Mucinous ovarian carcinoma (MOC) is a unique type of ovarian cancer. While many MOC patients have excellent survival, patients who experience recurrence have extremely poor prognosis. Identifying patients at the highest risk of recurrence is important for identifying which patients need the most aggressive treatment, and to identify where new treatment strategies are needed to improve survival. We use a large cohort of MOC patients to identify factors associated with high and low risk of recurrence. We show that once patients reach 5 years from diagnosis, their risk of recurrence is low. Patients with more advanced-stage disease and higher pathological grade of disease are more likely to experience recurrence, and their survival is significantly shorter. For early-stage MOC patients, survival time was similar whether they were treated with surgery plus chemotherapy, or whether they only had surgery. Patient survival time following recurrence is extremely poor (median 5 months); new treatment options are urgently needed to improve their survival.

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