Inicio  /  Cancers  /  Vol: 15 Par: 6 (2023)  /  Artículo
ARTÍCULO
TITULO

MRI Radiomics and Machine Learning for the Prediction of Oncotype Dx Recurrence Score in Invasive Breast Cancer

Valeria Romeo    
Renato Cuocolo    
Luca Sanduzzi    
Vincenzo Carpentiero    
Martina Caruso    
Beatrice Lama    
Dimitri Garifalos    
Arnaldo Stanzione    
Simone Maurea and Arturo Brunetti    

Resumen

The preoperative definition of the Oncotype DX recurrence score would be critical to identify breast cancer patients who could benefit from chemotherapy before surgery. In this work, we built a machine learning model applied to DCE-MRI images of a publicly available dataset to predict the Oncotype DX score in patients with breast cancer. As a result, the model achieved an accuracy of 60% in the training set and 63% (AUC = 0.66) in the test set. Our findings support the feasibility of radiomics and machine learning for the prediction of prognostic data in breast cancer, encouraging further, preferably multicenter, investigations to further improve the performance of the model and assess its generalizability.

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