Resumen
In this study, we aimed to establish a multi-residue analytical method for the simultaneous detection of chemical contaminants in eggs. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we developed an analytical method that can separate 244 compounds (including ß-agonists (25), imidazole and benzimidazoles (31), sulfonamides (22), antihistamines (10), ß-lactam (5), insecticides (7), quinolones (24), non-steroidal anti-inflammatory drugs (13), and steroidal hormones (38)) within 30 min. A new enhanced matrix removal-lipid (EMR-Lipid) material was used as a purified sorbent in the QuEChERS clean-up method. Excellent linearity (r > 0.9905) was achieved. Additionally, recoveries ranged between 51.33% and 118.28%, with repeatability (RSDr) and reproducibility (RSDwR) in the range of 1.01?14.22% and 1.08?14.96%, respectively. In all of the compounds, low limits of quantification (LOQs) = 5 µg kg-1 were found. Meanwhile, the detection limit (CCa) and detection capability (CCß) were 1.88?40.60 µg kg-1 and 2.85?407.19 µg kg-1, respectively. In conclusion, the evaluated method was shown to provide reliable screening, quantification, and identification of 244 multi-class chemicals in eggs and was successfully applied in real samples.