Inicio  /  Cancers  /  Vol: 13 Par: 4 (2021)  /  Artículo
ARTÍCULO
TITULO

Network Analysis Identifies Drug Targets and Small Molecules to Modulate Apoptosis Resistant Cancers

Samreen Fathima    
Swati Sinha and Sainitin Donakonda    

Resumen

With the thriving efficacy of cancers to evolve and evade treatment strategies targeting the apoptosis cell death mechanism, it has become imperative to reorient these conventional cancer therapy methods. In this study, we opted for an in-silico approach to mine the essential non-apoptotic cell death genes. We holistically examined the extensive protein?protein interaction networks in three such cancers with poor prognosis: colon adenocarcinoma, glioblastoma multiforme, and small cell lung cancer. Our analysis identified non-apoptotic cell death drug targets.

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