Resumen
The post-surgical treatment of atypical meningiomas is controversial in cases with gross total resection, because one out of two patients develops disease recurrence at five years. Factors able to predict the risk of recurrence may be useful in selecting patients who require adjuvant treatment. In this study, we analyzed the molecular alterations of 22 atypical meningiomas undergoing complete surgical resection and their statistical correlation with the risk of recurrence. The loss of one copy of chromosome 18q and the loss of both copies of CDKN2A/B gene were significantly associated with a shorter time to recurrence. Therefore, we suggest that atypical meningiomas could be tested routinely for these genetic alterations to identify cases for adjuvant treatment.