Inicio  /  Cancers  /  Vol: 14 Par: 4 (2022)  /  Artículo
ARTÍCULO
TITULO

A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma

Nabeel Merali    
Tarak Chouari    
Kayani Kayani    
Charles J. Rayner    
José I. Jiménez    
Jonathan Krell    
Elisa Giovannetti    
Izhar Bagwan    
Kate Relph    
Timothy A. Rockall    
Tony Dhillon    
Hardev Pandha    
Nicola E. Annels and Adam E. Frampton    

Resumen

This review summarizes the current literature related to the microbiome and pancreatic ductal adenocarcinoma (PDAC). The aim of this review is to explore the current role of the microbiome in the disease process, screening/diagnostics and to postulate the future role with regards to therapeutic strategies including chemotherapy, immunotherapy and surgery. We further explore the future of microbiome modulation (faecal microbiome transplants, bacterial consortiums, anti-microbials and probiotics), their applications and how we can improve the future of microbiome modulation in a bid to improve PDAC outcomes.

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