Inicio  /  Cancers  /  Vol: 13 Par: 14 (2021)  /  Artículo
ARTÍCULO
TITULO

Clinical and Imaging Features of Non-Small Cell Lung Cancer with G12C KRAS Mutation

Markus Y. Wu    
Eric W. Zhang    
Matthew R. Strickland    
Dexter P. Mendoza    
Lev Lipkin    
Jochen K. Lennerz    
Justin F. Gainor    
Rebecca S. Heist and Subba R. Digumarthy    

Resumen

KRAS G12C mutations are important oncogenic mutations in lung cancer that can now be targeted by allosteric small molecule inhibitors. We assessed the imaging features and patterns of metastases in these lung cancers compared to other mutated lung cancers. We found that KRAS G12C NSCLC has distinct primary tumor imaging features and patterns of metastasis when compared to those of NSCLC driven by other genetic alterations. These distinct imaging features may offer clues to its presence and potentially guide management in the future.

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