Resumen
Oesophageal adenocarcinomas are a distinct subtype of oesophageal cancer that has an increasing incidence in western countries. As these cancers are often late presenting, patients with locally advanced oesophageal adenocarcinomas are routinely treated with neoadjuvant chemotherapy with or without radiotherapy prior to surgery. Unfortunately, this neoadjuvant protocol demonstrates limited response, while exposing patients to the side effects of therapy. Biomarkers that can accurately predict neoadjuvant therapy response would save time, suffering, hospital resources and potentially improve survival.