Resumen
Latrophilin-1 is a latrotoxin receptor and is commonly found in the plasma membrane of neurons. This receptor has recently been identified in the plasma membrane of myeloid leukemia blasts but not in healthy leukocytes. We have shown that the development of drug resistance associated with ABCB1 overexpression leads to decreased regulation of latrophilin-1 in human acute myeloid leukemia cell lines. Here, we proved that latrophilin-1 expression also occurs in the myeloid blasts of patients newly diagnosed with myelodysplastic syndrome when ABCB1 is overexpressed. Furthermore, we provided the evidence that in case of ABCB1 overexpression in human acute myeloid leukemia cell lines, changes in the expression of latrophilin-1-regulated proteins occur that are thought to allow myeloid blasts to escape control of the immune system. All of the above changes in protein expression appear to be involved in the overall altered phenotype of neoplastic myeloid cells following ABCB1-mediated MDR development.