Resumen
The BRAFV600E point mutation is the most common driver mutation in papillary thyroid carcinoma (PTC) and is known to be associated with aggressive clinical features. However, the negative prognostic impact of BRAFV600E on PTC mostly depends on tumor characteristics, not on itself. Moreover, the prognosis of BRAFV600E-mutant PTCs varies widely implying the genetic diversity of this subtype. Additional genetic alterations other than BRAFV600E may be responsible for the aggressiveness of this group but to date, no mutations other than TERT promoter mutation have been identified. This study aimed to investigate the effect of additional genetic alterations, focusing on the mutations in genes encoding functional groups on survival in BRAFV600E-mutant PTCs. We observed that coexistence of mutations in BRAFV600E and the three functional groups had the worst survival in patients with PTCs compared with mutations in BRAFV600E and genes other than those associated with functional groups or mutations in only BRAFV600E.