Resumen
There is currently no effective treatment for Pancreatic Ductal Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in recent decades. The complexity in the tumor microenvironment (TME) is one of the main roots for the refractory nature of PDAC to treatment. Components of the PDAC TME are complex, dynamic, and closely reciprocate with each other from the early stages of pre-neoplastic lesion and during tumor progression. Detailed insight of the PDAC tumor microenvironment is needed for developing combined therapeutics that would target cancer cells and their supportive milieu for more efficient PDAC treatment.