Resumen
Protein tyrosine kinase 6 (PTK6) is a biomarker of poor prognosis in breast cancer, but its importance in other cancer types is unclear. In this review, we explore a potential role for PTK6 in colorectal cancer. PTK6 phosphorylates multiple substrates, including signal transduction proteins, RNA binding proteins, and transcription factors, many of which are involved in key colorectal cancer pathways. PTK6 is overexpressed in colorectal tumors vs. normal tissue and activates WNT signaling when localized to the membrane in colorectal cancer cells. It is also upregulated and promotes cell survival under DNA-damaging conditions. We propose that targeting PTK6 therapeutically in colorectal cancer could increase cancer cell sensitivity to standard chemotherapy treatment.