Resumen
High recurrence rates represent a major problem during the management of giant cell tumors of bone (GCTB). To evaluate the suitability of bioactive glasses (BGs) for the development of new therapeutic strategies, we analyzed the effects of BGs on cell viability and tumor formation. We observed a strong cytotoxic effect of BGs toward primary GCTB cell lines in vitro and a significant reduction of tumor formation and growth using a chicken chorioallantoic membrane (CAM) assay. These data suggest that BGs represent promising candidates for the treatment of GCTBs.