Resumen
Hormone replacement therapy (HRT) is used to improve the climacteric symptoms in postmenopausal women with a history of endometriosis. However, the impact of HRT on the malignant transformations of postmenopausal endometriosis is unclear. Therefore, this study examined the effects of HRT on the occurrences of various cancers in postmenopausal women with de novo or a history of endometriosis using the data from the Korean nationwide cohort study. In this study, the use of HRT increased the risk of uterine cancer, but it did not increase the risks of another nine cancers. Interestingly, the use of combined estrogen and progesterone reduced the risks of liver and thyroid cancers, and the use of estrogen alone reduced the risks of breast and lung cancers. Tibolone use was not associated with the risks of ten cancers. These results provide useful information on the use of HRT in women with de novo or a history of endometriosis.