Resumen
The objective of the study was to investigate the possibility of lncRNA HCP5-encoded peptide/protein and the role of the resulting product in triple-negative breast cancer. Our study revealed that lncRNA HCP5 encodes a 132-amino acid sequence, referred to as HCP5-132aa, which enhances the growth of triple-negative breast cancer cells by regulating ferroptosis. Moreover, breast cancer patients with elevated levels of HCP5-132aa had a worse prognosis. Our findings have revealed a regulatory mechanism of ferroptosis in triple-negative breast cancer that is modulated by an lncRNA-encoded product.