Resumen
Ovarian cancer is one of the leading causes of cancer deaths among women with gynecological cancers. Most of the cases are diagnosed late, at an advanced stage when cancer cells spread to the surrounding tissues and to distant organs. Even though OC metastasis is the main cause of poor clinical outcomes, the understanding of the process remains elusive. This results in a lack of effective treatments for patients with advanced disease. This review focuses on the dissemination routes of OC as well as different transition modes adopted by tumor cells. These migratory modes increase the plasticity of cancer cells and the metastasis rate. Novel drugs, aimed specifically at the mechanisms responsible for the switch between different invasion modes, are promising approaches for OC treatment.