Inicio  /  Cancers  /  Vol: 14 Par: 13 (2022)  /  Artículo
ARTÍCULO
TITULO

Methyladenosine Modification in RNAs: From Regulatory Roles to Therapeutic Implications in Cancer

Xiaolin Qu    
Yongqiu Zhang    
Xianzheng Sang    
Ding Ren    
Hong Zhao and Stephen T. C. Wong    

Resumen

Cancer remains a burden to the public health all over the world. An increasing number of studies have concentrated on the role of methyladenosine modifications on cancers. Methyladenosine modifications mainly include N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 2?-O-methyladenosine (m6Am), of which dynamic changes could modulate the metabolism of RNAs in eukaryotic cells. Mounting evidence has confirmed the crucial role of methyladenosine modification in cancer, offering possibilities for cancer therapy. In this review, we discussed the regulatory role of methyladenosine modification on cancer, as well as their potential for treatment.

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