Design Optimal Modified Internal Model Controller of Blood Glucose for Type I Diabetes

Resumen

Type I diabetic patients is a chronic condition marked by an abnormally large level of glucose in the blood. Persons with diabetes characterized by no insulin secretion within the pancreas (ß-cell) which also referred to as insulin-dependent diabetic Mellitus (IDDM). The treatment of type I diabetes counting on the delivery of exogenous insulin to succeed in the blood glucose level near the natural ranges (70-110mg/dL). In this paper, a Modified Internal Model Controller (MIMC) has been developed based on three different nonlinear functions to control the concentration of blood glucose levels under a disturbing meal. The parameters of the proposed control design are optimized by using Chaotic Particle Swarm Optimization (CPSO) technique. The model which is used to represent the artificial pancreas is a minimal model for Bergman. Simulations, based on MATLAB/Simulink, were performed to verify the performance of the proposed controller. The results showed the effectiveness of the proposed MIMC in controlling the behavior of glucose deviation to a sudden rise in blood glucose.