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You Sheng Toh and Carol Anne Hargreaves
Extensive medical research has revealed evidence of a strong association between hippocampus atrophy and age-related diseases such as Alzheimer?s disease (AD). Therefore; segmentation of the hippocampus is an important task that can help clinicians and r...
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Juan Jiang, Hong Liu, Xin Yu, Jin Zhang, Bing Xiong and Lidan Kuang
Precisely segmenting the hippocampus from the brain is crucial for diagnosing neurodegenerative illnesses such as Alzheimer?s disease, depression, etc. In this research, we propose an enhanced hippocampus segmentation algorithm based on 3D U-Net that can...
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Rong Zhou, Zhisheng Zhang and Yuan Wang
Deep reinforcement learning is one of the research hotspots in artificial intelligence and has been successfully applied in many research areas; however, the low training efficiency and high demand for samples are problems that limit the application. Ins...
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Myung-Joon Kim, Hyun-Woo Kim, Soo-Rin Lee, Na-Yeong Kim, Yoon-Ji Lee, Hui-Tae Joo, Seok-Nam Kwak and Sang-Heon Lee
The feeding and spawning grounds for seahorses have been lost due to nationwide coastal developments in South Korea. However, little information on the feeding ecology of the Korean seahorse (Hippocampus haema) is currently available. The main objective ...
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Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans and Klaudia Brix
Endolysosomal cathepsin expression and activities are differentially regulated in the cortex, striatum, hippocampus, and cerebellum of mice upon aging and/or cathepsin deficiencies.
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Sungeun Melanie Lee, Michaela M. Milillo, Beatrix Krause-Sorio, Prabha Siddarth, Lisa Kilpatrick, Katherine L. Narr, Jonathan P. Jacobs and Helen Lavretsky
Growing evidence supports the concept that bidirectional brain?gut microbiome interactions play an important mechanistic role in aging, as well as in various neuropsychiatric conditions including depression. Gray matter volume (GMV) deficits in limbic re...
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Fabiana Novellino, Maria Salsone, Roberta Riccelli, Carmelina Chiriaco, Giuseppe Argirò, Andrea Quattrone, José L. M. Madrigal, Luigi Ferini Strambi and Aldo Quattrone
This study aimed to investigate the structural covariance between the striatum and large-scale brain regions in patients with vascular parkinsonism (VP) compared to Parkinson?s disease (PD) and control subjects, and then explore the relationship between ...
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Hae-Jin Lee, Hae-Lim Kim, Dae-Young Lee, Dong-Ryung Lee, Bong-Keun Choi and Seung-Hwan Yang
We evaluated the effectiveness of Scrophularia buergeriana extract (Brainon) on cognitive dysfunction and determined its underlying mechanisms in a scopolamine (SCO)-treated mouse model of memory impairment. Brainon treatment for 28 days ameliorated the ...
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Jusik Park, Wookwang Cheon and Kijin Kim
To investigate the effects of long-term lithium treatment and low intensity endurance exercise on brain-derived neurotrophic factor (BDNF) expression and glycogen synthase kinase 3 beta (GSK3ß) activity in the hippocampus of obese rats. Fifty 10-week-old...
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Jong Min Oh, Moongi Ji, Mi-Jin Lee, Geum Seok Jeong, Man-Jeong Paik, Hoon Kim and Joo-Won Suh
The antidepressant-like activity of ethanol extract of Ziziphus jujuba Mill var. spinosa seeds (Semen Ziziphi Spinosae, SZS) was investigated by behavioral tests, such as a forced swimming test (FST), a tail-suspension test (TST), and an open field test ...
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