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Cosimo Cardellicchio, Valentino Laquintana, Rosa Maria Iacobazzi, Nunzio Denora, Antonio Scilimati, Maria Grazia Perrone and Maria Annunziata M. Capozzi
Sulindac is a well-known anti-inflammatory agent, sometimes employed as an adjuvant in antitumor therapy. Due to the recent interest in sulfoximine for its potential chemotherapeutics, we decided to transform sulindac and its methyl ester into the corres...
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Peramaiyan Rajendran, Hany Elsawy, Manal Alfwuaires and Azza Sedky
Plants from the family Brassicaceae produce brassinin (BSN), which is an essential indole phytoalexin. BSN can kill certain types of cancer cells. Using hepatocarcinoma (HCC) cells, we examined the molecular mechanisms of BSN. We found that HCC cell grow...
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Claudio Luparello, Rossella Branni, Giulia Abruscato, Valentina Lazzara, Simon Sugár, Vincenzo Arizza, Manuela Mauro, Vita Di Stefano and Mirella Vazzana
Echinoderms are an acknowledged source of bioactive compounds exerting various beneficial effects on human health. Here, we examined the potential in vitro anti-hepatocarcinoma effects of aqueous extracts of the cell-free coelomic fluid obtained from the...
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Takahiro Yamasaki, Issei Saeki, Yurika Kotoh-Yamauchi, Ryo Sasaki, Norikazu Tanabe, Takashi Oono, Takashi Matsuda, Takuro Hisanaga, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Yutaka Suehiro and Isao Sakaida
Recent success of systemic therapeutic agents, including combination immunotherapy, could promote a change in the treatment strategy in patients with advanced hepatocellular carcinoma (HCC). Although hepatic arterial infusion chemotherapy (HAIC) is a tre...
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Alessia Catalano, Domenico Iacopetta, Maria Stefania Sinicropi and Carlo Franchini
The diarylurea is a scaffold of great importance in medicinal chemistry as it is present in numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti-inflammatory properties. Some diarylureas, serine-threonine kinase or t...
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Kazuhiro Nouso, Takamasa Ohki, Tatsuya Yamashita, Haruyuki Takaki, Chien-Au Liu, Tae Wook Kang, Dong Ho Lee, So Jung Lee, Suyash Kulkarni, Deepa Shree and Masatoshi Tanaka
Many guidelines and standard therapies have been published for the treatment of hepatocellular carcinoma (HCC). Multiple options for the treatment of early to intermediate-stage HCC have resulted in several differences between the guidelines. In addition...
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Shiro Miyayama
Transarterial chemoembolization (TACE) is a first-line treatment for patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer stage B (BCLC-B). There are two major techniques of TACE: conventional TACE (cTACE) using iodized oil and g...
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Nagwan M. Abdel Samee
Hepatitis C virus (HCV) is one of the most dangerous viruses worldwide. It is the foremost cause of the hepatic cirrhosis, and hepatocellular carcinoma, HCC. Detecting new key genes that play a role in the growth of HCC in HCV patients using machine lear...
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Chih-Jan Ko, Chia-Jung Li, Meng-Yu Wu and Pei-Yi Chu
Hepatocarcinogenesis and distant metastasis pose major challenges for physicians. They are regulated by several genes, such as AKT, JUK, Wnt, and P53, and their expression activates several important processes such as cell proliferation, migration, motil...
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Sendren Sheng-Dong Xu, Chun-Chao Chang, Chien-Tien Su and Pham Quoc Phu
This paper discusses using computer-aided diagnosis (CAD) to distinguish between hepatocellular carcinoma (HCC), i.e., the most common type of primary liver malignancy and a leading cause of death in people with cirrhosis worldwide, and liver abscess bas...
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