Resumen
In this study, we evaluated antioxidant effect of alginate?okra extracts combination as topical application (ointment) for wound healing on diabetic mice. Characterization of alginate was used to determine structural characteristics and Okra fruit extract was determined total flavonoids content that have effect of the antioxidant properties. The antioxidant properties of extracts combination reduce blood-glucose levels to non-diabetic conditions (normal) significantly by topical application of diabetic open wound. These conditions can accelerate the activities of wound-healing processes on diabetic mice. The activities of wound-healing processes were performing periodically by histopathology test on skin tissue to evaluated wound healing parameters (wound area, neutrophils, macrophages, fibrocytes, fibroblasts and collagen densities).