Resumen
This study is the first to reveal the role and mechanism of ANLN (anillin, an actin-binding protein) in gallbladder cancer (GBC). Our research has led to the following conclusions: (1) ANLN promotes the proliferation and migration of gallbladder cancer cells. (2) Knockdown of ANLN promotes apoptosis and cell cycle arrest in GBC cells. (3) Knockdown of ANLN inhibits the Phosphatidylinositide 3-kinases (PI3K)/Serine/Threonine Kinase (AKT) signaling pathway, leading to the inhibition of GBC cell growth and migration. (4) ANLN activates the PI3K/AKT signaling pathway by regulating STRA6 in GBC cells.