Resumen
Superparamagnetic iron oxide nanoparticles (SPIONs) have a recognized potential for magnetic hyperthermia, and they are also being increasingly proposed as agents for photothermal treatment (photothermia), a biomedical modality where nanoparticles are excited by light to generate local hyperthermia. While it is known that endosomal internalization of SPIONs negatively affects magnetic hyperthermia, photothermia is not decreased. In an attempt to mimic nanoparticles clustering in endosomes, we herein investigate the effects of silica encapsulation and SPION clustering on both magnetic hyperthermia and photothermia.