Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Use
2.2. SOD3 Overexpression in Transgenic Mice
2.3. Immunoblotting
2.4. Fractionation
2.5. Electroretinography
2.6. Tissue Preparation, Immunofluorescence, Histology, and Morphometry
2.6.1. Immunofluorescence
2.6.2. Histology and Morphometry
2.7. Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling (TUNEL) ASSAY
2.8. RNA Sequencing
2.8.1. Mapping and Data Processing
2.8.2. Data Analysis
2.9. Statistical Analysis
3. Results
3.1. Elevated SOD3 Levels after Light Stress and in Retinal Pathologies
3.2. Retinal SOD3 Is Mainly Extracellular in Localization
3.3. Modulation of Retinal SOD3 Levels Leads to Functional and Structural Changes
3.4. SOD3 Overexpression Reduces Developmental Apoptosis
3.5. The Protective Effect of SOD3 Overexpression Is Not Maintained in the Adult Retina
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ikelle, L.; Naash, M.I.; Al-Ubaidi, M.R. Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis. Antioxidants 2021, 10, 1595. https://doi.org/10.3390/antiox10101595
Ikelle L, Naash MI, Al-Ubaidi MR. Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis. Antioxidants. 2021; 10(10):1595. https://doi.org/10.3390/antiox10101595
Chicago/Turabian StyleIkelle, Larissa, Muna I. Naash, and Muayyad R. Al-Ubaidi. 2021. "Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis" Antioxidants 10, no. 10: 1595. https://doi.org/10.3390/antiox10101595