Resumen
Testicular germ cell cancer (TGCC) is characterized by an extensive immune cell infiltration, which generates a pro-inflammatory tumor microenvironment (TME). The aim of this study is to compare the interaction of tumor cells representative of two major TGCC subtypes with the immune system in an in vitro coculture model. We found that the non-seminomatous cell line NTERA-2 lacks immunostimulatory capacity and even inhibits T cell and monocyte activity, thus sharply contrasting the opposing properties of the seminomatous cell line TCam-2. We hypothesize that different immunological characteristics of tumor cell subtypes may explain some of the clinical characteristics of TGCC.