Next Article in Journal
Molecular Characterization and Expression Analysis of Novel Interleukin-1 Family Member (nIL-1Fm) Gene in Nile Tilapia (Oreochromis niloticus)
Previous Article in Journal
Spot Charter Rate Forecast for Liquefied Natural Gas Carriers
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JMSE
Volume 10
Issue 9
10.3390/jmse10091271
jmse-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Bisphenol Analogs in Aquatic Environments and Their Effects on Marine Species—A Review

by
Jacopo Fabrello
and
Valerio Matozzo
*
Department of Biology, University of Padova, Via Ugo Bassi 58/B, 35121 Padova, Italy
*
Author to whom correspondence should be addressed.
J. Mar. Sci. Eng. 2022, 10(9), 1271; https://doi.org/10.3390/jmse10091271
Submission received: 20 August 2022 / Revised: 2 September 2022 / Accepted: 7 September 2022 / Published: 8 September 2022
(This article belongs to the Section Chemical Oceanography)
Versions Notes

Abstract

:
Bisphenol A analogs are currently used in manufacturing and as plasticizers as a substitute for bisphenol A. This replacement is taking place because bisphenol A is recognized as an endocrine disruptor chemical (EDC) that can also cause oxidative stress and genotoxic effects in aquatic species. Bisphenol A analogs have a similar chemical structure to BPA, raising doubts about their use as safer substitutes. This review intends to summarize the concentrations of BPA analogs found in aquatic environments and the effects of these emerging compounds on marine species. Generally, studies indicate that BPA analogs have similar effects to their precursor, altering the neuroendocrine system in several marine species. Furthermore, BPA analogs can cause oxidative stress and developmental alterations. The available information on the biological effects of BPA analogs suggests that more effort should be performed to assess the effects of these compounds in marine organisms.

1. Introduction

Bisphenols are synthetic and widely used compounds characterized by the presence of two hydroxyphenyl functionalities [1]. The most important bisphenol is bisphenol A (BPA), which was firstly synthesized in 1891 [2]. Its importance mainly derives from the discovery of its polymerization in the middle of the 20th century to make polycarbonate plastic. Indeed, it is a common plasticizer used in the production of polycarbonate plastics, epoxy resins used to line metal cans, and in many plastic consumer products including toys, water pipes, drinking containers, eyeglass lenses, sports safety equipment, dental monomers, medical equipment, and consumer electronics [3]. The BPA world production in 2002 was 2.8 million metric tons [2], rose to a consumption of 7.7 million metric tons in 2015, and is expected to reach 10.6 million metric tons in 2022 [4], and more than 100 tons of BPA are annually released into the atmosphere [5]. BPA is used also as a color developer in thermal paper and its usage in thermal paper manufactured in the EU and placed on the EU market was 2776 tons in 2017 [6]. BPA is considered as a chemical compound of very high concern due to its toxicity on reproduction and its endocrine disrupting effects both in humans and other animals [7,8,9], leading to BPA restrictions whereby it was removed from many industries and banned in the manufacture of baby bottles by many governments such as USA, Canada, and the EU. Furthermore, the EU has limited the BPA usage to less than 0.02% by weight in thermal paper since January 2020 [10].

1.1. Bisphenol A Analogs Production and Usage

Recently, BPA has been replaced by other similar compounds named bisphenol A analogs (BPA analogs) (Table 1). Currently, at least 148 different substances show the presence of the “bisphenol” moiety [11]. This group includes 17 bisphenols with the generic “bisphenol” structure, and “bisphenol derivatives” that have constituents with structural features common to bisphenols [11]. Bisphenols differ in both the chemical group between the two hydroxyphenyls and the presence of other chemical groups, such as brominated and chlorinated compounds.
The main BPA analogs recently used in the production of polycarbonate plastics and epoxy resins are bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF). Moreover, BPF is also used in food packaging, liners, water pipes, dental sealants, industrial floors, grouts, electrical varnishes, coatings, lacquers, plastics, adhesives, and tissue substitutes [1,12]. In addition, BPS has also several uses, such as epoxy glues, thermal receipt papers, sulfonated poly (ether ketone ether sulfone), and as an additive in dyes agents [1]. Another bisphenol A analog, namely, BPAF, is used in common polymer applications, such as a cross-linker in fluoroelastomers, electronics, and optical fibers, as a high-performance monomer for polyimides, polyamides, polyesters, polycarbonate copolymers and in specialty polymer applications such as plastic optical fibers and waveguides [1]. Similarly, bisphenol AP (BPAP), is used as a plasticizer and flame retardant in synthesizing plastic, rubber, polymer materials, the chemical industry, and in the medical industry [13]. Furthermore, brominated bisphenols have been produced, such as tetrabromobisphenol A (TBBPA) and tetrabromobisphenol S (TBBPS) and their analogs/derivates, which are used as flame retardants [14].
The production amount of BPA analogs is usually not available, but it is considered increasing [1,15]. Indeed, BPS usage has increased twice from 200 tons in 2016 to 397 tons in 2017 (98% increase) [9], and the European Food Safety Authority (EFSA) reports that the annual production of BPS is 1000–10,000 tons [16]. Regarding BPAF, its annual production in the USA was in the range of approximately 4.5–220 tons from 1986 to 2002, while its manufacture/import in the EU is 100–1000 tons per year [17,18]. In the case of brominated bisphenols, the most used is TBBPA with a global production of over 170,000 metric tons/year [19].
Despite their new usage, BPA analogs are considered hormonally active due to their similar chemical structure to BPA. Indeed, these substances can cause endocrine-disrupting effects acting as estrogenic, progesteronic, and anti-androgenic compounds [12,15]. For instance, BPS, which was first synthesized in 1869 and used as a dye, was introduced into cash-register receipts in 2006 as a speculatively safer compound instead of BPA [20]. However, it has been recently reported that it has genotoxic and estrogenic activities, similarly to BPA, being able to bind to estrogen receptors in vitro [20]. Moreover, in the case of bisphenol F diglycidyl ether (BPF-DGE), the EU banned its use as a food packaging material and settled a Tolerably Daily Intake (TDI) for the sum of bisphenol A diglycidyl ether (BPADGE) and its metabolites (BADGE·H2O and BADGE·2H2O) at 0.15 mg kg−1 bw per day, while for BADGE chlorohydrins, the restriction was settled at 1 mg kg−1 of food [21].

1.2. Biodegradation of Bisphenols

Bisphenols reach the aquatic environment not only from wastewater treatment plants (WWTPs) and discharge from urban and industrial areas, but they can also be continuously released and adsorbed by microplastics [22]. After their release, bisphenols can be degraded in several ways in the environment including photodegradation, oxidation, and biodegradation. However, bisphenols are mainly biodegraded. Indeed, several organisms including bacteria, fungi, algae, and plants can degrade bisphenols [23]. In the case of BPA, it can be degraded in other organic compounds by more than ninety bacterial strains throughout many pathways [23,24,25]. In addition, some microorganisms can degrade several bisphenol analogs. For example, the Sphingomonas species can biodegrade up to six bisphenol analogs, including BPS, BPF, BPB, BPE, BPZ, and BPC. Likewise, Cupriavidus and Sphingobium can biodegrade six different bisphenols, while Bacillus and Pseudomonas can degrade at least five or four bisphenols, respectively [23].
However, the persistence in the water of bisphenols is highly variable. Indeed, some bisphenols can be rapidly degraded in river water such as BPF, which was completely biodegraded in 37 days [26]. On the contrary, the biodegradation of BPAF, BPE, and BPB was minimal, while the biodegradation of BPS appeared to be higher than that of BPA, but lower than that of BPF in rivers [26]. In addition, BPAF has a half-life that ranges from 15 to 180 days in water [1]. BPA in seawater persists longer than in rivers, with a BPA degradation that started from 40 to 60 days, posing a risk for marine organisms [27]. Moreover, bisphenols biodegradability in seawater was ranked as BPF ≫ BPA > BPP > BPE > BPB ≫ BPS [1]. Lastly, in marine sediment under aerobic conditions, the half-life of BPA is 14.5 days [28].

1.3. Occurrence of Bisphenols in Aquatic Environments

In aquatic environments, the mostly detected bisphenol is BPA with a concentration that is usually in the range of ng/L in both surface waters (wastewater treatment plants, streams, rivers, and lakes) and seawaters, as reported in Table 2. However, some reports reveal that its concentrations can reach hundreds of ng/L to tens of µg/L, exceeding in some cases the predicted no-effect concentration for water (PNEC), set at 1500 ng/L by the EU [29]. In addition, the EU established a PNEC value of 150 ng/L for BPA in marine water [29]. Bisphenol A analogs are often found at lower concentrations than BPA, in the range of a few ng/L [30,31,32]. However, it has been reported that their concentrations can reach hundreds and thousands of ng/L. Indeed, BPAF was recorded at a mean concentration of 140 ng/L in surface water in China [33], while BPF reached 2850 ng/L and BPS reached 65,600 ng/L in surface water of Japan and China, respectively [34,35].
In the marine environment, bisphenol analogs have a common concentration from very few ng/L up to tens of ng/L [30,36,37], even if their concentrations can reach upper concentrations, as in the case of BPF that had a maximum concentration of 282 ng/L and 1470 ng/L in seawater in South China and in the Tokyo Bay, respectively [30,34]. These values are close to the PNEC value and could be passed due to the higher use and environmental release of BPA analogs. Moreover, bisphenol A analogs, such as BPA, can also be bioaccumulated by marine animals, as observed in shrimps, crabs, mollusks, and fishes [30,37], and can be transferred through the food web and cross-generation as observed in the humpback Dolphins (Sousa chinensis), in which six bisphenols (BPA, BPAF, BPB, BPF, BPP, and BPS) have been detected even in fetuses [38].

2. Effects of Bisphenols on Marine Species

2.1. Effects of Bisphenol A

The effects of bisphenols have been evaluated on some marine species, such as microalgae, mollusks, rotifers, sea urchins, polychaetae, crustaceans, fishes, and mammals. However, BPA is still the most studied bisphenol, while the effects of the other compounds are substantially unknown. BPA is considered as an EDC, being able to mimic the natural estrogens causing impairment in hormonal sensitivity and responsiveness. It is well known that BPA can also affect the immune system, antioxidant enzymes, neuroendocrine system, and embryo development in humans [62]. Similarly, several studies demonstrated that BPA could cause detrimental effects on marine species. BPA can alter the reproductive system of marine species, as demonstrated in Mytilus edulis specimens exposed for 3 weeks to 50 μg/L of bisphenol A [63]. The authors also observed a slight increase in phospho-proteins in the mantle gonadal tissue of females, and after histological investigations, they observed atretic oocytes in half of the BPA-exposed mantles, while on the other half there were post-spawning stage gonads [63]. Effects on the reproductive system were also reported in the mud crab Macrophthalmus japonicus where a significant upregulation of the vitellogenin (VTG) gene was observed in the ovaries after 96 h of exposure to the tested concentration (1, 10, and 30 µg/L) and a significant upregulation of VTG gene was also observed in hepatopancreas at 30 µg/L. Moreover, a significantly higher VTG gene expression was observed after 7 days of exposure at 1 µg/L in hepatopancreas and under all the tested concentrations in ovaries [64]. The same authors investigated the effect of BPA on the molting process. After one day of exposure, there was an ecdysone receptor gene up-regulation (EcR) in the hepatopancreas at 1, 10, and 30 µg/L, while in gills only 1 and 10 µg/L caused a significant up-regulation. However, the EcR gene expression in hepatopancreas was downregulated at 1 and 30 µg/L after 4 days. Interestingly, after one week of exposure, an opposite trend between the two tissues was observed, with the 10 µg/L treatment that caused a significant decrease in expression in gills and a significant increase in hepatopancreas [65].
In another crustacean species, namely, the whiteleg shrimp Litopenaeus vannamei, exposure to 2 µg/L of BPA induced a significantly smaller gonad-somatic index with a consequent delay in the gonad development stage with respect to the controls. Moreover, exposed shrimps had a lower oxygen consumption rate, an increased ammonia extraction rate, and a downregulation of metabolism-related gene expression. In addition, the authors observed an upregulation of gonadal development-related hormones and the expression of gene-encoding regulatory hormones [66]. It was also highlighted that BPA can cause embryotoxic effects [67,68,69]. For instance, in the mussel Mytilus galloprovincialis, BPA interfered with shell formation at different larval stages with spatial alteration of the expression of genes involved in shell formation and in serotoninergic system development [70]. In the same species, Balbi et al. [71] observed several gene expression alterations in embryos hatched from eggs previously exposed to 10 μg/L of BPA. In a similar study, in which fertilized eggs of Haliotis diversicolor supertexta were exposed to four BPA concentrations (0.05, 0.2, 2, and 10 μg/mL), it was demonstrated that BPA can affect embryonic development. Moreover, the authors concluded that BPA could markedly reduce embryo hatchability, increase developmental malformation, and suppress the metamorphosis behavior of larvae [72]. Larvae malformations were also recorded in the two ascidian species Ciona robusta and Ciona intestinalis after exposure to concentrations higher than 10 μM [69]. Furthermore, most of the embryos of the sea urchin Hemicentrotus pulcherrimus exposed to 10 μM of BPA for 24 or 48 h after fertilization showed a suppressed development by the hatching stage [67]. In addition, juveniles of H. pulcherrimus exposed for 80 days to 0.5 µM of BPA showed a reduction in the relative test diameter [67]. However, the authors reported that BPA effects on early development were less remarkable than that of ethynyl estradiol [67]. An analog study reported that BPA can affect the development of embryos of the sea urchin Paracentrotus lividus. Indeed, animals exposed to 300 µg/L of BPA showed spermiotoxic and embryotoxic effects and skeleton malformation was observed in plutei [68]. Moreover, larvae skeletal malformations were also observed in the embryos of sea urchin Arbacia lixula after BPA exposure [73]. Lastly, fertilized eggs of the sea urchin Lytechinus pictus exposed to BPA showed failed cytokinesis leading to multipolar spindles in a dose-dependent manner [74].
BPA can also affect the immune system in bivalves. Indeed, BPA injected in M. galloprovincialis (25 nM nominal concentration in the hemolymph) caused a significant lysosomal membrane destabilization in hemocytes at all the post-injection times (6, 12, and 24 h). Moreover, BPA changed the phosphorylation state of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT), indicating that BPA can affect kinase-mediated cell signaling in mussel hemocytes in vivo [75]. Furthermore, in the bivalve Tegillarca granosa total hemocyte count (THC) was reduced after 2 weeks of exposure to 10 ng/L and 100 ng/L of BPA and a decrease in red granulocyte percentage and an increase in both basophil granulocyte and hyalinocyte was reported [76]. In addition, the phagocytic activities of hemocytes were significantly reduced and the content of γ-aminobutyric acid, dopamine, and acetylcholine in hemolymph was increased [76]. On the contrary, the expression of four immune-related genes and genes encoding modulatory enzymes and receptors for neurotransmitters was significantly suppressed [76]. An impairment of the neuro system was also observed in the claw muscles of the artic spider crab Hyas araneus in which there was a significant reduction in acetylcholinesterase activity (AChE) after 3 weeks of exposure to 50 µg/L of BPA [77]. In another study, the crab Charybdis japonica was exposed for 1, 3, 6, 9, and 15 days to 0.125, 0.25, 0.5, and 1 mg/L, respectively. The authors reported a reduction in THC values in crabs exposed to 1 mg/L for 1, 3, and 6 days; 6 days of exposure to 0.5 mg/L of BPA also caused a THC reduction [78]. They also observed that superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), lysozyme (LSZ), and phenoloxidase (PO) activities reached the highest values during the first week and then decreased during the second week of exposure in both hemolymph and hepatopancreas, while malondialdehyde content (MDA) gradually increased over time following the exposure [78]. Histological analysis revealed that the rough endoplasmic reticulum of hepatopancreas cells appeared swollen and reduced in number [78]. Moreover, vacuoles, lysosomes, and myeloid bodies were observed in the hepatopancreas cells [78]. In addition, in the same crab species, there was a significantly increased expression of the heat shock protein gene HSP90 under all the tested concentrations (0.05, 0.5, 1 mg/L) after 12, 24, 48, and 96 h of exposure [79].
BPA can cause detrimental effects on the antioxidant system also in bivalves. Indeed, in specimens of M. galloprovincialis injected with 50 μL of BPA solutions (from a 10 mM stock solution in ethanol diluted in artificial seawater), containing respectively, 3, 15, and 60 ng BPA, corresponding to a nominal concentration of BPA 3, 15, and 60 ng/g dry weight or per mussel, BPA caused an increased gene expression of the estrogen receptor MeER2 and induced downregulation of antioxidant genes, catalase, and metallothioneins 24 h post injection [80]. In addition, BPA altered the activity of CAT, glutathione S-transferase (GST), glutathione reductase (GR), and the total glutathione amount [80]. Moreover, exposure for 7 days of Perna viridis to 98, 996, and 10,111 ng/L of BPA had immunomodulatory, genotoxic, and endocrine-disruptive effects [81].
The effects of BPA were also evaluated in polychaetae. In Ophryotrocha diadema BPA caused a significant reduction in the number of laid eggs only after five weeks of exposure at the highest concentration tested (1.4611 mg/L) [82]. Furthermore, in the polychaete Perinereis aibuhitensis exposed for 4, 7, and 14 days to 10, 50, and 100 µg/L, respectively, BPA caused the increase in G protein alpha subunit gene expression in both the body wall and in the head, on which there was the higher induced expression [83]. Lastly, recent studies have shown that some degradation products and metabolites of BPA have much higher estrogenicity or toxicity than BPA. For instance, 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), a metabolite of bisphenol A, has shown an estrogenic activity approximately 1000-fold higher than BPA [84,85].

2.2. Effects of Bisphenol A Analogs

The effects of BPA analogs are poorly studied in marine species. However, in a recent study, BPF, BPS, and BPA were tested in the marine rotifer Brachionus koreanus for 24 h [86]. The authors reported that both BPA and BPF caused a reduction in cumulative offspring. In addition, 10 mg/L of BPA, 10 mg/L of BPF, and 15 mg/L of BPF caused a significant reduction in life span. Moreover, the three bisphenols increased the reactive oxygen species level (ROS), with BPS and BPF increasing the ROS and GST levels at almost all the tested concentrations (1, 5, and 10 mg/L) [86]. BPF as well as BPA significantly altered the expression level of cytochrome P450 (CYP) and GST genes [86].
Furthermore, in the brackish water flea Diaphanosoma celebensis, the gene expression of seven ecdysteroid pathway-related genes (cyp314a1, EcRA, EcRB, USP, nvd, HR3, and E75) were altered after exposure for 48 h at high concentrations of BPA (0.12, 0.6, and 3.0 mg/L), BPS (0.92, 4.6, and 23.0 mg/L), and BPF (0.6, 1.0, and 5.0 mg/L), suggesting an ecdysteroid signaling pathway disruption and an alteration of the endocrine system. However, the expression patterns of BPS and BPF were different from those of BPA [87,88]. In the same species exposed to the same concentrations, BPA, BPS, and BPF differently modulated the gene expression of the estrogen-related receptors, vitellogenin and vitellogenin receptors, indicating that these compounds can also affect the normal reproduction-related pathway [89]. Moreover, an in silico study on the Pacific oyster Magallana gigas revealed that BPF has a high affinity for the estrogen receptor (ER) and that BPA has a higher binding energy for ER than the estrogen hormone itself [90]. In a recent in vitro study, TBBPA, BPA-E (Bisphenol A BIS (2,3-dihydroxy propyl) ether), and BPAF tested at 50 µM caused the reduction in residual carboxylesterase activity in the digestive gland extracts of both Octopus vulgaris and Sepia officinalis [91]. Similarly, the three BPA analogs caused an inhibition effect also in the hemolymph of O. vulgaris [91]. Recently, the effects of several bisphenol A analogs on β-esterases were also tested in the sea turtle Caretta caretta. The results showed that only TBBPA (at 50 μM) significantly inhibit the plasmatic carboxyl esterase activity, however, TBBPA did not inhibit acetylcholinesterase [92]. Furthermore, in the marine amphipod Gammarus aequicauda exposed to 0.25, 0.5, and 1 mg/L of BPA, BPF, or BPS for 24 h, there was a general increase in DNA damage in both hemocytes and spermatozoa. In detail, BPF caused a significant increase in DNA damage at all the tested concentrations in hemocytes and in spermatozoa at 1 mg/L, while the BPS exposure increased the mean DNA damage level with respect to the controls in both somatic and germ cells, but not significantly. The authors concluded that both BPF and BPS caused lower DNA damage than BPA [93].
In a recent study, juveniles of the brown trout Salmo trutta were exposed for 2 or 8 weeks to 2 or 20 mg/kg fish. After 2 weeks, the level of the thyroid hormone triiodothyronine (T3) in plasma was elevated after Bisphenol S exposure at the high concentration and paralleled by an increase in micronucleated cells. BPS did not cause statistical differences in the hematocrit, hemoglobin levels, or glucose levels in comparison with the control. However, there was a significantly higher hematocrit level in fish exposed to the high dose of BPS compared to fish exposed to the low dose of BPS after 2 weeks of exposure. On the contrary, the vitellogenin levels in blood were not altered by BPS, and only the higher dose of BPA increased the level. After 2 weeks, T3 levels were significantly higher in fish treated with the high dose of BPS compared with controls, but thyroxin T4 levels were not altered. At the same time as the exposure, the high dose of BPS increased the micronuclei percentage in the erythrocytes, while after 8 weeks, the same treatment decreased the percentage of binucleated erythrocytes [94]. Furthermore, the hepatocytes of the rainbow trout Oncorhyncus mykiss treated for 24 h with BPS (0, 15.63, 31.25, 62.50, 125, 250, and 500 µM) showed that cytotoxicity increased in a concentration-dependent manner. Moreover, all the tested BPS concentrations caused a reduction in SOD activity, while CAT and GPX activity was generally increased at higher concentrations. GST activity was significantly increased at a concentration of 31.25 µM or higher, while GST Theta 1-1 activity and the reduced glutathione content (GSH) were decreased at these concentrations. Moreover, the oxidative damage measured as malondialdehyde content increased at 125, 250, and 500 µM of BPS [95]. In an analog study, the hepatocytes of rainbow trout were exposed to BPF using the same experimental design. As in the case of BPS, BPF increased dose-dependently its cytotoxic effects. The malondialdehyde content was increased at BPF concentrations between 15.63 and 250 µM, whereas it remained unchanged at 500 µM. Interestingly, SOD and CAT activities were increased and decreased, respectively, in all treatment concentrations. Moreover, the GSH level increased with concentrations of BPF between 15.63 and 250 µM but decreased significantly at 500 µM. In addition, GPX and GST were significantly increased at a BPF concentration from 31.25 µM, and at 125 µM, respectively. The authors concluded that the toxic mechanism of BPF was mainly based on cell membrane damage and oxidative stress, influencing the antioxidant defenses [96]. The effect of BPS was also tested on the juveniles of olive flounders (Paralichthys olivaceus) that were injected with a concentration of 50 mg/kg. Treatment caused a transcriptome alteration in the liver. In particular, BPS significantly increased the transcription of egg process and vitellogenesis-related genes, including zona pellucida sperm-binding proteins, and estrogen receptors, with increases in plasma 17β-estradiol (E2) and VTG concentrations. In addition, there was an increased gene expression of genes involved in antioxidant defense systems, while genes involved in innate immunity were decreased [97]. Moreover, there was an increased activity of both CAT and GST in the liver [97].
Recently, specimens of medaka (Oryzias melastigma) were exposed for 70 days to 200 µg/L of BPA, BPF, BPAF, or their mixture [98]. After 70 days of exposure to BPAF, males showed a higher body weight and body length. On the other side, the condition factor of males was significantly reduced by the mixture and increased in females owing to BPF exposure [98]. In addition, the BPAF-exposed fishes had a survival rate significantly lower than controls. Moreover, the histological analysis indicated that bisphenol exposure led to vacuolization and local lesions in the liver, especially in the BPAF group. These results are like those observed by Peng et al. [78] in crabs exposed to BPA. In addition, medaka fishes showed an altered antioxidant enzyme activity, with a reduction in both SOD and CAT activity in the liver of males exposed to BPAF or MIX. In females, both BPF and BPAF caused a reduction in the total swimming distance, while in males this reduction was observed only in the mixed treatment. All the bisphenols caused an up-regulation of genes involved in lipid synthesis and metabolism in the liver of female fish and, interestingly, all genes involved in eukaryotic ribosome biogenesis were downregulated in females exposed to BPAF [98]. In males, the differentially expressed genes were mainly involved in steroid biosynthesis, arachidonic acid metabolism, nicotinate, and nicotinamide metabolism [98]. Moreover, BPAF appeared to cause an estrogenic effect with an increased coriogenins and vitellogenins gene expression in the liver of male fishes [98].
Bisphenol A analogs can alter the microbiome of the mussel M. galloprovincialis larvae, as demonstrated after exposure to BPA and BPF (10 μg/L). The results indicated that after 24 h post fertilization, BPF altered the microbiome, with an alteration in the abundance of six genera, such as potential pathogens (Vibrio, Arcobacter, and Tenacibaculum) and genera involved in xenobiotic biotransformation (Oleispira). Similarly, after 48 h post fertilization, BPF induced changes in five genera. Interestingly, BPF caused similar effects to BPA, but lower than those caused by 17β-estradiol [99].
Very few studies have been conducted on microalgae. A recent study demonstrated an alteration of the antioxidant system in the microalgae Chlorella pyrenoidosa exposed for 6 days to BPS (5.0, 10.0, 15.0, 20.0, and 40.0 mg/L), BPA, and their mixture [100]. On the 6th day, BPA was 3.7 times more toxic than BPS and the bisphenol mixture and showed higher inhibition effects with respect to the single bisphenols, indicating a synergistic effect. BPF caused an alteration in chlorophyll A content; in particular, the concentration of 5 mg/L increased the chlorophyll content, while the other concentrations decreased the chlorophyll content in a dose-dependent manner. Similarly, the higher doses of the mixture caused a chlorophyll A level decrease, even if, at the initial exposure times, the low doses had a stimulation effect [100]. Furthermore, 6 days of exposure at 15, 20, and 40 mg/L of BPS increased ROS levels, and peroxidase activity, while the SOD activity was enhanced by all the tested concentrations [100]. In the case of the mixture, only the two lowest concentrations increased the ROS levels and the activities of SOD and peroxidase increased gradually with the increase in the combined concentration of BPA and BPS [100]. Lastly, the malondialdehyde amount was increased by all the BPF concentrations and by most mixture concentrations [100].
As a concluding remark, it can be highlighted that BPA analogs can act as EDCs and can also affect the immune system, antioxidant system, genetics, and behavior in aquatic species. BPA is going to be replaced with structurally similar compounds that are speculatively considered safer compounds. In the context of higher BPA analog usage and release into aquatic environments, recent studies have highlighted that the marine concentrations can already pose environmental risks to non-target species. However, the effects of BPA analogs and their mixtures on marine organisms are still mainly unknown and need to be deeply investigated.

Author Contributions

J.F. designed and wrote the present manuscript. V.M. wrote and supervised the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Chen, D.; Kannan, K.; Tan, H.; Zheng, Z.; Feng, Y.L.; Wu, Y.; Widelka, M. Bisphenol analogues other than BPA: Environmental occurrence, human exposure, and toxicity—A review. Environ. Sci. Technol. 2016, 50, 5438–5453. [Google Scholar] [CrossRef] [PubMed]
  2. Rochester, J.R. Bisphenol A and human health: A review of the literature. Reprod. Toxicol. 2013, 42, 132–155. [Google Scholar] [CrossRef]
  3. Vandenberg, L.N.; Hauser, R.; Marcus, M.; Olea, N.; Welshons, W.V. Human exposure to bisphenol A (BPA). Reprod Toxicol. 2007, 24, 139–177. [Google Scholar] [CrossRef] [PubMed]
  4. Almeida, S.; Raposo, A.; Almeida-González, M.; Carrascosa, C. Bisphenol A: Food exposure and impact on human health. Compr. Rev. Food. Sci. Food. Saf. 2018, 17, 1503–1517. [Google Scholar] [CrossRef]
  5. Vandenberg, L.N.; Maffini, M.V.; Sonnenschein, C.; Rubin, B.S.; Soto, A.M. Bisphenol-A and the great divide: A review of controversies in the field of endocrine disruption. Endocr. Rev. 2009, 30, 75–95. [Google Scholar] [CrossRef]
  6. ECHA. Use of Bisphenol A and Its Alternatives in Thermal Paper in the EU—2018 Update; European Chemicals Agency: Helsinki, Finland, 2019. [Google Scholar]
  7. ECHA 2017A: ECHA (European Chemicals Agency). Inclusion of BPA as a Substance of Very High Concern (Reason for Inclusion: Toxic for Reproduction—Article 57c) in the Candidate List for Eventual Inclusion in Annex XIV. Decision of the European Chemicals Agency. 2017. Available online: https://echa.europa.eu/documents/10162/c11b5b68-67f4-8044-53a6-26759a106c80 (accessed on 11 August 2022).
  8. ECHA 2017 B: ECHA (European Chemicals Agency). Inclusion of BPA as a Substance of Very High Concern (Reason for Inclusion: Endocrine Disrupting Properties—Article 57f Human Health) in the Candidate List for Eventual Inclusion in Annex XIV. Decision of the European Chemicals Agency. 2017. Available online: https://echa.europa.eu/documents/10162/20a23653-34b1-bb48-4887-7ea77bedc637 (accessed on 11 August 2022).
  9. ECHA. Inclusion of BPA as a Substance of Very High Concern (Reason for Inclusion: Endocrine Disrupting Properties—Article 57f Environment) in the Candidate List for Eventual Inclusion in Annex XIV; Decision of the European Chemicals Agency; European Chemicals Agency: Helsinki, Finland, 2018. [Google Scholar]
  10. EU. Commission regulation 2016/2235 of 12 December 2016 amending annex XVII to regulation (EC) No 1907/2006 of the European parliament and of the council concerning the registration, evaluation, authorisation and restriction of chemicals (REACH) as regards bisphenol A. Off. J. Eur. Union 2016, L337, 3–5. [Google Scholar]
  11. ECHA. Assessment of Regulatory Needs. Version 1.0, 16 December 2021. Available online: https://echa.europa.eu/documents/10162/3448017/GMT_109_Bisphenols_Report_public_23502_en.pdf (accessed on 12 August 2022).
  12. Rochester, J.R.; Bolden, A.L. Bisphenol S and F: A systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ. Health Perspect. 2015, 123, 643–650. [Google Scholar] [CrossRef]
  13. Zhang, L.; Fang, P.; Yang, L.; Zhang, J.; Wang, X. Rapid method for the separation and recovery of endocrine-disrupting compound bisphenol AP from wastewater. Langmuir 2013, 29, 3968–3975. [Google Scholar] [CrossRef]
  14. Liu, A.F.; Qu, G.B.; Yu, M.; Liu, Y.W.; Shi, J.B.; Jiang, G.B. Tetrabromobisphenol-A/S and nine novel analogs in biological samples from the Chinese Bohai Sea: Implications for trophic transfer. Environ. Sci. Technol. 2016, 50, 4203–4211. [Google Scholar] [CrossRef]
  15. Usman, A.; Ikhlas, S.; Ahmad, M. Occurrence, toxicity and endocrine disrupting potential of Bisphenol-B and Bisphenol-F: A mini-review. Toxicol. Lett. 2019, 312, 222–227. [Google Scholar] [CrossRef]
  16. EFSA; FitzGerald, R.; Van Loveren, H.; Civitella, C.; Castoldi, A.F.; Giovanni Bernasconi, G. Assessment of New Information on Bisphenol S (BPS) Submitted in Response to the Decision under REACH Regulation (EC) No 1907/2006; EFSA Supporting Publication; European Food Safety Authority (EFSA): Parma, Italy, 2020; p. 39. [Google Scholar]
  17. Hu, Y.; Zhu, Q.; Yan, X.; Liao, C.; Jiang, G. Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: A review. Environ. Res. 2019, 178, 108732. [Google Scholar] [CrossRef] [PubMed]
  18. ECHA. Bisphenol AF, Substance Infocard. Available online: https://echa.europa.eu/substance-information/-/substanceinfo/100.014.579 (accessed on 25 July 2022).
  19. Su, H.; Guan, G.; Ahmed, R.Z.; Lyu, L.; Li, Z.; Jin, X. TBBPA stimulated cell migration of endometrial cancer via the contribution of NOX-generated ROS in lieu of energy metabolism. J. Hazard. Mater. 2020, 400, 123204. [Google Scholar] [CrossRef] [PubMed]
  20. Russo, G.; Barbato, F.; Grumetto, L. Monitoring of bisphenol A and bisphenol S in thermal paper receipts from the Italian market and estimated transdermal human intake: A pilot study. Sci. Total Environ. 2017, 599, 68–75. [Google Scholar] [CrossRef]
  21. EU. Commission regulation (EC) No 1895/2005 of 18 November 2005 on the restriction of use of certain epoxy derivatives in materials and articles intended to come into contact with food. Off. J. Eur. Union 2005, L302, 28–32. [Google Scholar]
  22. Liu, X.; Shi, H.; Xie, B.; Dionysiou, D.D.; Zhao, Y. Microplastics as both a sink and a source of bisphenol A in the marine environment. Environ. Sci. Technol. 2019, 53, 10188–10196. [Google Scholar] [CrossRef]
  23. De Morais Farias, J.; Krepsky, N. Bacterial degradation of bisphenol A and its analogues: An overview. Res. Sq. 2022. [Google Scholar] [CrossRef]
  24. Ike, M.; Jin, C.S.; Fujita, M. Biodegradation of bisphenol A in the aquatic environment. Water Sci. Technol. 2000, 42, 31–38. [Google Scholar] [CrossRef]
  25. Zhang, W.; Yin, K.; Chen, L. Bacteria-Mediated bisphenol A degradation. Appl. Microbiol. Biotechnol. 2013, 97, 5681–5689. [Google Scholar] [CrossRef]
  26. Frankowski, R.; Zgoła-Grześkowiak, A.; Smułek, W.; Grześkowiak, T. Removal of bisphenol A and its potential substitutes by biodegradation. Appl. Biochem. Biotechnol. 2020, 191, 1100–1110. [Google Scholar] [CrossRef]
  27. Kang, J.H.; Kondo, F. Bisphenol A degradation in seawater is different from that in river water. Chemosphere 2005, 60, 1288–1292. [Google Scholar] [CrossRef]
  28. Ying, G.G.; Kookana, R.S. Degradation of five selected endocrine-disrupting chemicals in seawater and marine sediment. Envrion. Sci. Technol. 2003, 37, 1256–1260. [Google Scholar] [CrossRef]
  29. EU. European Union Updated Risk Assessment Report. Environment Addendum of April 2008 (To be Read in Conjunction with Published EU RAR of BPA, 2003) 4,4′-ISOPROPYLIDENEDIPHENOL (Bisphenol-A) Part 1 Environment; European Commission, Joint Research Centre, Institute for Health and Consumer Protection: Luxembourg, 2008. [Google Scholar]
  30. Zhao, X.; Qiu, W.; Zheng, Y.; Xiong, J.; Gao, C.; Hu, S. Occurrence, distribution, bioaccumulation, and ecological risk of bisphenol analogues, parabens and their metabolites in the Pearl River Estuary, South China. Ecotoxicol. Environ. Saf. 2019, 180, 43–52. [Google Scholar] [CrossRef] [PubMed]
  31. Jin, H.; Zhu, L. Occurrence and partitioning of bisphenol analogues in water and sediment from Liaohe River Basin and Taihu Lake, China. Water Res. 2016, 103, 343–351. [Google Scholar] [CrossRef] [PubMed]
  32. Wang, Q.; Feng, Q.; Hu, G.; Gao, Z.; Zhu, X.; Epri, J.E. Simultaneous determination of seven bisphenol analogues in surface water by solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. Microchem. J. 2022, 175, 107098. [Google Scholar] [CrossRef]
  33. Wang, Q.; Chen, M.; Shan, G.; Chen, P.; Cui, S.; Yi, S.; Zhu, L. Bioaccumulation and biomagnification of emerging bisphenol analogues in aquatic organisms from Taihu Lake, China. Sci. Total Environ. 2017, 598, 814–820. [Google Scholar] [CrossRef]
  34. Yamazaki, E.; Yamashita, N.; Taniyasu, S.; Lam, J.; Lam, P.K.; Moon, H.B.; Jeong, Y.; Kannan, P.; Achyuthan, H.; Munuswamy, N.; et al. Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan, China, Korea and India. Ecotoxicol. Environ. Saf. 2015, 122, 565–572. [Google Scholar] [CrossRef]
  35. Huang, C.; Wu, L.H.; Liu, G.Q.; Shi, L.; Guo, Y. Occurrence and ecological risk assessment of eight endocrine-disrupting chemicals in urban river water and sediments of South China. Arch. Environ. Contam. Toxicol. 2018, 75, 224–235. [Google Scholar] [CrossRef]
  36. Xie, J.; Zhao, N.; Zhang, Y.; Hu, H.; Zhao, M.; Jin, H. Occurrence and partitioning of bisphenol analogues, triclocarban, and triclosan in seawater and sediment from East China Sea. Chemosphere 2022, 287, 132218. [Google Scholar] [CrossRef]
  37. Zhao, N.; Hu, H.; Zhao, M.; Liu, W.; Jin, H. Occurrence of free-form and conjugated bisphenol analogues in marine organisms. Environ. Sci. Technol. 2021, 55, 4914–4922. [Google Scholar] [CrossRef]
  38. Guo, Y.; Yu, R.Q.; Zhang, L.; Liang, Y.; Liu, Z.; Sun, X.; Wu, Y. Cross-Generational Impacts of Diet Shift on Bisphenol Analogue Loads in Indo-Pacific Humpback Dolphins (Sousa chinensis). Environ. Sci. Technol. 2022, 56, 10764–10774. [Google Scholar] [CrossRef]
  39. Wang, H.; Liu, Z.H.; Zhang, J.; Huang, R.P.; Yin, H.; Dang, Z.; Wu, P.; Liu, Y. Insights into removal mechanisms of bisphenol A and its analogues in municipal wastewater treatment plants. Sci. Total Environ. 2019, 692, 107–116. [Google Scholar] [CrossRef] [PubMed]
  40. Peteffi, G.P.; Fleck, J.D.; Kael, I.M.; Rosa, D.C.; Antunes, M.V.; Linden, R. Ecotoxicological risk assessment due to the presence of bisphenol A and caffeine in surface waters in the Sinos River Basin—Rio Grande do Sul—Brazil. Braz. J. Biol. 2019, 79, 712–721. [Google Scholar] [CrossRef] [PubMed]
  41. Zhang, H.; Zhang, Y.; Li, J.; Yang, M. Occurrence and exposure assessment of bisphenol analogues in source water and drinking water in China. Sci. Total Environ. 2019, 655, 607–613. [Google Scholar] [CrossRef] [PubMed]
  42. Yan, Z.; Liu, Y.; Yan, K.; Wu, S.; Han, Z.; Guo, R.; Chen, M.; Yang, Q.; Zhang, S.; Chen, J. Bisphenol analogues in surface water and sediment from the shallow Chinese freshwater lakes: Occurrence, distribution, source apportionment, and ecological and human health risk. Chemosphere 2017, 184, 318–328. [Google Scholar] [CrossRef] [PubMed]
  43. Wang, Q.; Zhang, Y.; Feng, Q.; Hu, G.; Gao, Z.; Meng, Q.; Zhu, X. Occurrence, distribution, and risk assessment of bisphenol analogues in Luoma Lake and its inflow rivers in Jiangsu Province, China. Environ. Sci. Pollut. Res. 2022, 29, 1430–1445. [Google Scholar] [CrossRef]
  44. Ozhan, K.; Kocaman, E. Temporal and spatial distributions of bisphenol A in marine and freshwaters in Turkey. Arch. Environ. Contam. Toxicol. 2019, 76, 246–254. [Google Scholar] [CrossRef]
  45. Pojana, G.; Gomiero, A.; Jonkers, N.; Marcomini, A. Natural and synthetic endocrine disrupting compounds (EDCs) in water, sediment and biota of a coastal lagoon. Environ. Int. 2007, 33, 929–936. [Google Scholar] [CrossRef]
  46. Arditsoglou, A.; Voutsa, D. Occurrence and partitioning of endocrine-disrupting compounds in the marine environment of Thermaikos Gulf, Northern Aegean Sea, Greece. Mar. Pollut. Bull. 2012, 64, 2443–2452. [Google Scholar] [CrossRef]
  47. Basheer, C.; Lee, H.K.; Tan, K.S. Endocrine disrupting alkylphenols and bisphenol-A in coastal waters and supermarket seafood from Singapore. Mar. Pollut. Bull. 2004, 48, 1161–1167. [Google Scholar] [CrossRef]
  48. Bayen, S.; Zhang, H.; Desai, M.M.; Ooi, S.K.; Kelly, B.C. Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore’s marine environment: Influence of hydrodynamics and physical–chemical properties. Environ. Pollut. 2013, 182, 1–8. [Google Scholar] [CrossRef]
  49. Bayen, S.; Estrada, E.S.; Juhel, G.; Kit, L.W.; Kelly, B.C. Pharmaceutically active compounds and endocrine disrupting chemicals in water, sediments and mollusks in mangrove ecosystems from Singapore. Mar. Pollut. Bull. 2016, 109, 716–722. [Google Scholar] [CrossRef] [PubMed]
  50. Beck, I.C.; Bruhn, R.; Gandrass, J.; Ruck, W. Liquid chromatography–tandem mass spectrometry analysis of estrogenic compounds in coastal surface water of the Baltic Sea. J. Chromatogr. A 2005, 1090, 98–106. [Google Scholar] [CrossRef] [PubMed]
  51. Wang, H.; Tang, S.; Zhou, X.; Gao, R.; Liu, Z.; Song, X.; Zeng, F. Urinary concentrations of bisphenol analogues in the south of China population and their contribution to the per capital mass loads in wastewater. Environ. Res. 2022, 204, 112398. [Google Scholar] [CrossRef] [PubMed]
  52. Česen, M.; Ahel, M.; Terzić, S.; Heath, D.J.; Heath, E. The occurrence of contaminants of emerging concern in Slovenian and Croatian wastewaters and receiving Sava river. Sci. Total Environ. 2019, 650, 2446–2453. [Google Scholar] [CrossRef] [PubMed]
  53. Huang, Z.; Zhao, J.L.; Yang, Y.Y.; Jia, Y.W.; Zhang, Q.Q.; Chen, C.E.; Liu, Y.S.; Yang, B.; Xie, L.; Ying, G.G. Occurrence, mass loads and risks of bisphenol analogues in the Pearl River Delta region, South China: Urban rainfall runoff as a potential source for receiving rivers. Environ. Pollut. 2020, 263, 114361. [Google Scholar] [CrossRef]
  54. Kiejza, D.; Kotowska, U.; Polinska, W.; Karpinska, J. USAEME-GC/MS Method for Easy and Sensitive Determination of Nine Bisphenol Analogues in Water and Wastewater. Molecules 2022, 27, 4977. [Google Scholar] [CrossRef]
  55. Yin, J.; Meng, Z.; Zhu, Y.; Song, M.; Wang, H. Dummy molecularly imprinted polymer for selective screening of trace bisphenols in river water. Anal. Methods 2011, 3, 173–180. [Google Scholar] [CrossRef]
  56. Lalwani, D.; Ruan, Y.; Taniyasu, S.; Yamazaki, E.; Kumar, N.J.; Lam, P.K.; Wang, X.; Yamashita, N. Nationwide distribution and potential risk of bisphenol analogues in Indian waters. Ecotoxicol. Environ. Saf. 2020, 200, 110718. [Google Scholar] [CrossRef]
  57. Caban, M.; Stepnowski, P. The quantification of bisphenols and their analogues in wastewaters and surface water by an improved solid-phase extraction gas chromatography/mass spectrometry method. Environ. Sci. Pollut. Res. 2020, 27, 28829–28839. [Google Scholar] [CrossRef]
  58. Chiriac, F.L.; Paun, I.; Pirvu, F.; Pascu, L.F.; Galaon, T. Occurrence and Fate of Bisphenol A and its Congeners in Two Wastewater Treatment Plants and Receiving Surface Waters in Romania. Environ. Toxicol. Chem. 2021, 40, 435–446. [Google Scholar] [CrossRef]
  59. Wilkinson, J.L.; Hooda, P.S.; Swinden, J.; Barker, J.; Barton, S. Spatial distribution of organic contaminants in three rivers of Southern England bound to suspended particulate material and dissolved in water. Sci. Total Environ. 2017, 593, 487–497. [Google Scholar] [CrossRef] [PubMed]
  60. Yang, S.; Wang, S.; Liu, H.; Yan, Z. Tetrabromobisphenol A: Tissue distribution in fish, and seasonal variation in water and sediment of Chaohu Lake, China. Environ. Sci. Pollut. Res. 2012, 19, 4090–4096. [Google Scholar] [CrossRef] [PubMed]
  61. Harrad, S.; Abdallah, M.A.E.; Rose, N.L.; Turner, S.D.; Davidson, T.A. Current-Use brominated flame retardants in water, sediment, and fish from English lakes. Environ. Sci. Technol. 2009, 43, 9077–9083. [Google Scholar] [CrossRef] [PubMed]
  62. Ma, Y.; Liu, H.; Wu, J.; Yuan, L.; Wang, Y.; Du, X.; Wang, R.; Marwa, P.W.; Petlulu, P.; Chen, X.; et al. The adverse health effects of bisphenol A and related toxicity mechanisms. Environ. Res. 2019, 176, 108575. [Google Scholar]
  63. Aarab, N.; Lemaire-Gony, S.; Unruh, E.; Hansen, P.D.; Larsen, B.K.; Andersen, O.K.; Narbonne, J.F. Preliminary study of responses in mussel (Mytilus edilus) exposed to bisphenol A, diallyl phthalate and tetrabromodiphenyl ether. Aquat. Toxicol. 2006, 78, S86–S92. [Google Scholar] [CrossRef]
  64. Park, K.; Jo, H.; Kim, D.K.; Kwak, I.S. Environmental pollutants impair transcriptional regulation of the vitellogenin gene in the burrowing mud crab (Macrophthalmus japonicus). Appl. Sci. 2019, 9, 1401. [Google Scholar] [CrossRef]
  65. Park, K.; Kim, W.S.; Kwak, I.S. Characterization and transcriptional response of ecdysone receptor gene in the mud crab Macrophthalmus japonicus: Effects of osmotic stress and endocrine disrupting chemicals. Ocean. Sci. J. 2019, 54, 611–620. [Google Scholar] [CrossRef]
  66. Han, Y.; Shi, W.; Tang, Y.; Zhou, W.; Sun, H.; Zhang, J.; Yan, M.; Hu, L.; Liu, G. Microplastics and bisphenol A hamper gonadal development of whiteleg shrimp (Litopenaeus vannamei) by interfering with metabolism and disrupting hormone regulation. Sci. Total Environ. 2022, 810, 152354. [Google Scholar] [CrossRef]
  67. Kiyomoto, M.; Kikuchi, A.; Unuma, T.; Yokota, Y. Effects of ethynylestradiol and bisphenol A on the development of sea urchin embryos and juveniles. Mar. Biol. 2006, 149, 57–63. [Google Scholar] [CrossRef]
  68. Özlem, Ç.A.; Hatice, P. Effects of bisphenol A on the embryonic development of sea urchin (Paracentrotus lividus). Environ. Toxicol. 2008, 23, 387–392. [Google Scholar] [CrossRef]
  69. Mercurio, S.; Messinetti, S.; Barzaghi, B.; Pennati, R. Comparing the sensitivity of two cogeneric ascidian species to two plastic additives: Bisphenol A and the flame retardant tris (chloro-propyl) phosphate. Eur. Zool. J. 2022, 89, 437–445. [Google Scholar]
  70. Miglioli, A.; Balbi, T.; Besnardeau, L.; Dumollard, R.; Canesi, L. Bisphenol A interferes with first shell formation and development of the serotoninergic system in early larval stages of Mytilus galloprovincialis. Sci. Total Environ. 2021, 758, 144003. [Google Scholar] [CrossRef] [PubMed]
  71. Balbi, T.; Franzellitti, S.; Fabbri, R.; Montagna, M.; Fabbri, E.; Canesi, L. Impact of bisphenol A (BPA) on early embryo development in the marine mussel Mytilus galloprovincialis: Effects on gene transcription. Environ. Pollut. 2016, 218, 996–1004. [Google Scholar] [PubMed]
  72. Zhou, J.; Zhu, X.S.; Cai, Z.H. The impacts of bisphenol A (BPA) on abalone (Haliotis diversicolor supertexta) embryonic development. Chemosphere 2011, 82, 443–450. [Google Scholar]
  73. Arslan, O.C.; Parlak, H. Effects of bisphenol-A on the embryological development of the sea urchin Arbacia Lixula (Linnaeus, 1758). Fresenius Environ. Bull. 2008, 17, 127. [Google Scholar]
  74. George, O.; Bryant, B.K.; Chinnasamy, R.; Corona, C.; Arterburn, J.B.; Shuster, C.B. Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells. ACS Chem. Biol. 2008, 3, 167–179. [Google Scholar]
  75. Canesi, L.; Betti, M.; Lorusso, L.C.; Ciacci, C.; Gallo, G. ‘In vivo’ effects of Bisphenol A in Mytilus hemocytes: Modulation of kinase-mediated signalling pathways. Aquat. Toxicol. 2005, 71, 73–84. [Google Scholar]
  76. Tang, Y.; Zhou, W.; Sun, S.; Du, X.; Han, Y.; Shi, W.; Liu, G. Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa. Environ. Pollut. 2020, 265, 115115. [Google Scholar]
  77. Minier, C.; Forget-Leray, J.; Bjørnstad, A.; Camus, L. Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider crab, Hyas araneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl phthalate. Mar. Pollut. Bull. 2008, 56, 1410–1415. [Google Scholar]
  78. Peng, Y.Q.; Wang, M.J.; Chen, H.G.; Chen, J.H.; Gao, H.; Huang, H.H. Immunological responses in haemolymph and histologic changes in the hepatopancreas of Charybdis japonica (A. Milne-Edwards, 1861) (Decapoda: Brachyura: Portunidae) exposed to bisphenol A. J. Crustac. Biol. 2018, 38, 489–496. [Google Scholar] [CrossRef] [Green Version]
  79. Park, K.; Kwak, I.S. Characterize and gene expression of heat shock protein 90 in marine crab Charybdis japonica following bisphenol A and 4-nonylphenol exposures. Environ. Health Toxicol. 2014, 29, e2014002. [Google Scholar] [PubMed]
  80. Canesi, L.; Borghi, C.; Ciacci, C.; Fabbri, R.; Vergani, L.; Gallo, G. Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas. Mol. Cell. Endocrinol. 2007, 276, 36–44. [Google Scholar] [PubMed]
  81. Juhel, G.; Bayen, S.; Goh, C.; Lee, W.K.; Kelly, B.C. Use of a suite of biomarkers to assess the effects of carbamazepine, bisphenol A, atrazine, and their mixtures on green mussels, Perna viridis. Environ. Toxicol. Chem. 2017, 36, 429–441. [Google Scholar] [PubMed]
  82. Ruberto, S.; Buono, D.; Santovito, A. Polychaetes as bioindicators of environmental Pollution: Impact of bisphenol A on the reproduction rate of Ophryotrocha diadema (Åkesson, 1976) (eunicida: Dorvilleidae). Zool. Ecol. 2021, 31, 61–65. [Google Scholar]
  83. Zhao, H.; Zhou, Y.; Li, Y.; Li, S.; Yang, D. Molecular cloning and expression of the gene for G protein alpha subunit induced by bisphenol A in marine polychaete Perinereis aibuhitensis. Environ. Toxicol. Pharmacol. 2014, 37, 521–528. [Google Scholar] [PubMed]
  84. Okuda, K.; Takiguchi, M.; Yoshihara, S. In vivo estrogenic potential of 4- methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, an active metabolite of bisphenol A, in uterus of ovariectomized rat. Toxicol. Lett. 2010, 197, 7–11. [Google Scholar]
  85. Yoshihara, S.; Mizutare, T.; Makishima, M.; Suzuki, N.; Fujimoto, N.; Igarashi, K.; Ohta, S. Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: Their structures and estrogenic potency. Toxicol. Sci. 2004, 78, 50–59. [Google Scholar] [CrossRef]
  86. Park, J.C.; Lee, M.C.; Yoon, D.S.; Han, J.; Kim, M.; Hwang, U.K.; Jung, J.H.; Lee, J.S. Effects of bisphenol A and its analogs bisphenol F and S on life parameters, antioxidant system, and response of defensome in the marine rotifer Brachionus koreanus. Aquat. Toxicol. 2018, 199, 21–29. [Google Scholar]
  87. In, S.; Yoon, H.W.; Yoo, J.W.; Cho, H.; Kim, R.O.; Lee, Y.M. Acute toxicity of bisphenol A and its structural analogues and transcriptional modulation of the ecdysone-mediated pathway in the brackish water flea Diaphanosoma celebensis. Ecotoxicol. Environ. Saf. 2019, 179, 310–317. [Google Scholar]
  88. In, S.; Cho, H.; Lee, Y.M. Identification of ecdysteroid pathway-related genes and their transcriptional modulation in the brackish water flea Diaphanosoma celebensis exposed to bisphenol analogs. Toxicol. Environ. Health. Sci. 2021, 13, 261–268. [Google Scholar]
  89. In, S.; Cho, H.; Lee, K.W.; Won, E.J.; Lee, Y.M. Cloning and molecular characterization of estrogen-related receptor (ERR) and vitellogenin genes in the brackish water flea Diaphanosoma celebensis exposed to bisphenol A and its structural analogues. Mar. Pollut. Bull. 2020, 154, 111063. [Google Scholar]
  90. Raj, A.; Nair, S.N.; Abdulvahab, R.; Ittoop, G. In-Silico Modelling of Interaction Between Environmental Xenoestrogens and Estrogen Receptor of Pacific Oyster (Magallana gigas [Thunberg, 1793]) Using AutoDock. Inform. Stud. 2022, 9. [Google Scholar]
  91. Omedes, S.; Andrade, M.; Escolar, O.; Villanueva, R.; Freitas, R.; Solé, M. B-Esterases characterisation in the digestive tract of the common octopus and the European cuttlefish and their in vitro responses to contaminants of environmental concern. Environ. Res. 2022, 210, 112961. [Google Scholar] [PubMed]
  92. Sole, M.; Bassols, A.; Labrada-Martagón, V. Plasmatic B-esterases as potential biomarkers of exposure to marine plastics in loggerhead turtles. Environ. Res. 2022, 213, 113639. [Google Scholar] [PubMed]
  93. Cosentino, S.; Aureli, F.; Iannilli, V. Bisphenols A and its analogues induce genotoxic damage in marine and freshwater amphipods. Environ. Adv. 2022, 7, 100183. [Google Scholar]
  94. Frenzilli, G.; Martorell-Ribera, J.; Bernardeschi, M.; Scarcelli, V.; Jönsson, E.; Diano, N.; Moggio, M.; Guidi, P.; Sturve, J.; Asker, N. Bisphenol A and bisphenol S induce endocrine and chromosomal alterations in brown trout. Front. Endocrinol. 2021, 12, 645519. [Google Scholar]
  95. Kaptaner, B.; Yılmaz, C.; Aykut, H.; Doğan, E.; Fidan, C.; Bostancı, M.; Yıldız, F. Bisphenol S leads to cytotoxicity-induced antioxidant responses and oxidative stress in isolated rainbow trout (Oncorhyncus mykiss) hepatocytes. Mol. Biol. Rep. 2021, 48, 7657–7666. [Google Scholar] [PubMed]
  96. Aykut, H.; Kaptaner, B. In vitro effects of bisphenol F on antioxidant system indicators in the isolated hepatocytes of rainbow trout (Oncorhyncus mykiss). Mol. Biol. Rep. 2021, 48, 2591–2599. [Google Scholar]
  97. Jung, J.H.; Moon, Y.S.; Kim, B.M.; Lee, Y.M.; Kim, M.; Rhee, J.S. Comparative analysis of distinctive transcriptome profiles with biochemical evidence in bisphenol S-and benzo [a] pyrene-exposed liver tissues of the olive flounder Paralichthys olivaceus. PLoS ONE 2018, 13, e0196425. [Google Scholar]
  98. Li, X.; Liu, Y.; Chen, Y.; Song, X.; Chen, X.; Zhang, N.; Li, H.; Guo, Y.; Wang, Z.; Dong, Z. Long-Term exposure to bisphenol A and its analogues alters the behavior of marine medaka (Oryzias melastigma) and causes hepatic injury. Sci. Total Environ. 2022, 841, 156590. [Google Scholar]
  99. Balbi, T.; Vezzulli, L.; Lasa, A.; Pallavicini, A.; Canesi, L. Insight into the microbial communities associated with first larval stages of Mytilus galloprovincialis: Possible interference by estrogenic compounds. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. 2020, 237, 108833. [Google Scholar] [CrossRef] [PubMed]
  100. Li, J.; Wang, Y.; Li, N.; He, Y.; Xiao, H.; Fang, D.; Chen, C. Toxic Effects of Bisphenol A and Bisphenol S on Chlorella pyrenoidosa under Single and Combined Action. Int. J. Environ. Res. Public Health 2022, 19, 4245. [Google Scholar] [CrossRef] [PubMed]
Table
Table 1. Main bisphenol A analogs and their chemical characteristics.
Table 1. Main bisphenol A analogs and their chemical characteristics.
Name (Abbreviation)CAS
Number		Structural FormulaLog KowMolecular Weight (g/mol)
Bisphenol A (BPA)80-05-7Jmse 10 01271 i0013.32228.29
Bisphenol AF (BPAF)1478-61-1Jmse 10 01271 i0023.69336.23
Bisphenol AP (BPAP)1571-75-1Jmse 10 01271 i0034.38290.36
Bisphenol B (BPB)77-40-7Jmse 10 01271 i0043.95242.31
Bisphenol BP (BPBP)1844-01-5Jmse 10 01271 i0054.96352.43
Bisphenol C (BPC)79-97-0Jmse 10 01271 i0064.32256.34
Bisphenol E (BPE)2081-08-5Jmse 10 01271 i0073.12214.26
Bisphenol F (BPF)620-92-8Jmse 10 01271 i0082.91200.23
Bisphenol FL (BPFL)3236-71-3Jmse 10 01271 i0094.90350.42
Bisphenol G (BPG)127-54-8Jmse 10 01271 i0106.04312.45
Bisphenol M (BPM)13595-25-0Jmse 10 01271 i0116.10346.46
Bisphenol P (BPP)2167-51-3Jmse 10 01271 i0126.10346.46
Bisphenol PH (BPPH)24038-68-4Jmse 10 01271 i0136.59380.48
Bisphenol S (BPS)80-09-1Jmse 10 01271 i0141.29250.27
Bisphenol TMC (BPTMC)129188-99-4Jmse 10 01271 i0155.87310.43
Bisphenol Z (BPZ)843-55-0Jmse 10 01271 i0164.44268.35
Note: The reported Log Kow value is the experimental or predicted average.
Table
Table 2. Bisphenol analogs concentrations in WWTPs, surface waters, and seawaters around the world.
Table 2. Bisphenol analogs concentrations in WWTPs, surface waters, and seawaters around the world.
CompoundBody Water, (Country)Min–Max Concentration (Mean) (ng/L)Reference
BPAWWTP influent (China)3–62,010 (mean = 2031)[39]
Surface water (Japan)3.1–120[34]
Surface water (Korea)1.0–272[34]
Surface water (China)ND–98[34]
Surface water (Brazil)ND–517[40]
Surface water (India)ND–1950[34]
Surface water (China)22.9–3360[33]
Surface water (China)ND–34.9 (mean = 12.8)[41]
Surface water (China)4.2–141[31]
Surface water (China)28–560[42]
Surface water (China)78.9–310[43]
Surface water (Turkey)4620–29,920[44]
Surface water (China)75.6–7480 (mean = 922)[35]
Seawater (Italy)ND–145[45]
Seawater (China)9.48–173[30]
Seawater (Turkey)4160–16,920[44]
Seawater (East China Sea)2.3–49 (mean = 18)[37]
Seawater (Tokyo Bay)ND–431 (mean = 325)[34]
Seawater (Greece)10.6–52.3 (mean = 25)[46]
Seawater (Singapore)ND–2470[47]
Seawater (Singapore)ND–694[48]
Seawater (Singapore)6–1493[49]
Seawater (Baltic Sea)ND–5.7[50]
Seawater (East China Sea)2.7–52 (mean = 23)[36]
BPAFWWTP influent (China)ND–9 (mean = 2)[39]
WWTP (China)6.6–160 (mean = 17)[51]
WWTP (Slovenia–Croatia)0.0367–3.4 (mean = 1.47)[52]
WWTP (China)ND–18.5[53]
Surface water (China)ND–2.58 (mean = 1.01)[53]
Surface water (China)mean=140 ng/L[33]
Surface water (China)ND–10.8 (mean = 3)[41]
Surface water (China)0.13–11[31]
Surface water (China)0.7–84[42]
Seawater (South China)0.40–3.59[30]
Seawater (East China Sea)0.12–0.91 (mean = 0.21)[36]
Seawater (East China Sea)ND–0.57 (mean = 0.24)[37]
BPAPWWTP influent (China)1.1–75 (mean = 26)[39]
WWTP (China)ND–21[51]
Surface water (Slovenia–Croatia)0.54–0.903 (mean = 0.704)[52]
Surface water (China)ND–0.39[31]
Surface water (China)1–56[42]
BPBWWTP (Slovenia–Croatia)27.1[52]
WWTP influent (China)1–8 (mean = 4)[39]
WWTP (China)ND–8 (mean = 2.2)[51]
WWTP (Poland)29.29–62.49[54]
Surface water (China)ND–14.3 (mean = 1.0)[41]
Surface water (China)ND–28[42]
Surface water (China)ND–7.9[43]
Surface water (China)ND–5.7[32]
Seawater (South China)0.17–13.1[30]
BPBPWWTP (China)ND–0.21[53]
Surface water (China)ND–0.43[53]
BPCWWTP (Poland)ND–7.57[54]
WWTP influent (China)6[39]
WWTP (China)ND–360 (mean = 68)[51]
WWTP (China)ND–0.38[53]
BPEWWTP (Slovenia–Croatia)476[52]
WWTP influent (China)2–84 (mean = 16)[39]
WWTP (Poland)25.16–58.71[54]
WWTP (China)ND–31 (mean = 16)[51]
WWTP (China)ND–7.71[53]
Surface water (China)ND–2.69[53]
Surface water (China)ND–6.18 (mean = 0.98)[41]
Surface water (China)ND–20.3[55]
BPFWWTP (Slovenia–Croatia)2.54–117 (mean = 44.3)[52]
WWTP influent (China)3–90 (mean = 39)[39]
Wastewater (India)ND–333[56]
WWTP (China)ND–180 (mean = 26)[51]
WWTP (China)0.52–271[53]
Surface water (Japan)76–2850[34]
Surface water (China)0.24–34.4[53]
Surface water (Korea)ND–1300[34]
Surface water (China)ND–1110[34]
Surface water (India)ND–289[34]
Surface water (India)ND–209[56]
Surface water (China)21.3–230[43]
Surface water (China)ND–12.56 (mean = 2.18)[41]
Surface water (China)ND–474 (mean = 82.8)[35]
Surface water (China)ND–5.6 (mean = 0.83)[31]
Surface water (China)ND–1600[42]
Seawater (East China Sea)ND–0.65 (mean = 0.31)[37]
Seawater (South China)2.37–282 ng/L[30]
Seawater (East China Sea)ND–0.91[36]
Seawater (Tokyo Bay)ND–1470 (mean = 373)[34]
BPFLSurface water (China)ND–0.069[31]
Surface water (China)ND–2.21[30]
BPGWWTP (Poland)ND–33.08[54]
WWTP (China)ND–1.76[53]
Surface water (China)ND–2.47[53]
BPMSeawater (East China Sea)ND–0.74[36]
BPPWWTP influent (China)1.5–27 (mean = 8)[39]
WWTP (China)2.7–300 (mean = 17)[51]
Surface water (China)ND–1.93[53]
Surface water (Slovenia–Croatia)6.45[52]
Surface water (China)0.27–1.53[30]
BPPHWWTP (China)ND–0.38[53]
Surface water (China)ND–0.68[53]
BPTMCWWTP (China)0.09–5.3[53]
Surface water (China)ND–101 (mean=8.8)[53]
BPSWWTP (Slovenia–Croatia)108–435 (mean = 316)[52]
WWTP (India)ND–438[56]
WWTP influent (China)7–318 (mean = 54)[39]
WWTP (China)90–1100 (mean = 290)[51]
WWTP (China)0.10–932[53]
Surface water (Japan)ND–8.7[34]
Surface water (China)0.07–133 (mean = 12.7)[53]
Surface water (Korea)ND–42[34]
Surface water (China)ND–135[34]
Surface water (China)19.9–65,600 (mean = 3720)[35]
Surface water (India)ND–7200[34]
Surface water (Slovenia–Croatia)1.68–35.2 (mean = 9)[52]
Surface water (China)mean= 27.6 ng/L[33]
Surface water (India)ND–341[56]
Surface water (Poland)ND–1584[57]
Surface water (Romania)6.15–8.23[58]
Surface water (England)ND–306[59]
Surface water (China)ND–5.2 (mean = 1.1)[41]
Surface water (China)0.22–67[31]
Surface water (China)ND–1600[42]
Surface water (China)3.2–7.8[32]
Seawater (East China Sea)0.15–12 (mean = 2.2)[36]
Seawater (South China)1.6–59.8[30]
Seawater (East China Sea)0.12–11 (mean = 3.7)[37]
Seawater (Tokyo Bay)ND–15 (mean = 8.5)[34]
BPZWWTP (China)ND–540 (mean=7)[51]
WWTP (Poland)24.64–66.62[54]
WWTP influent (China)3–151 (mean = 77)[39]
WWTP (China)ND–1.15[53]
Surface water (Slovenia–Croatia)0.25–9.11 (mean = 4.68)[52]
Surface water (China)ND–1.09[53]
Surface water (China)ND–0.70 (mean = 0.054)[31]
Surface water (China)ND–45[42]
Surface water (China)ND–2.8[32]
TBBPASurface water (China)23.9–224[55]
Surface water (China)ND–4870[60]
Surface water (England)0.14–3.2[61]
Seawater (East China Sea)0.25–25 (mean = 2.3)[36]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Fabrello, J.; Matozzo, V. Bisphenol Analogs in Aquatic Environments and Their Effects on Marine Species—A Review. J. Mar. Sci. Eng. 2022, 10, 1271. https://doi.org/10.3390/jmse10091271

AMA Style

Fabrello J, Matozzo V. Bisphenol Analogs in Aquatic Environments and Their Effects on Marine Species—A Review. Journal of Marine Science and Engineering. 2022; 10(9):1271. https://doi.org/10.3390/jmse10091271

Chicago/Turabian Style

Fabrello, Jacopo, and Valerio Matozzo. 2022. "Bisphenol Analogs in Aquatic Environments and Their Effects on Marine Species—A Review" Journal of Marine Science and Engineering 10, no. 9: 1271. https://doi.org/10.3390/jmse10091271

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop