Resumen
Late diagnosis and chemoresistance are key obstacles to ovarian cancer treatment success. Thus, there exists a need to develop new markers to detect ovarian cancer at an early stage as well as predict chemoresistance. We have developed a nanosensor platform that reacts with extracellular vesicles and cisplatin as well as predicts early-stage cancers and chemoresistance. Mechanistically, we have shown that chemoresistant OVCA cells produce large amounts of plasma gelsolin (pGSN) that induces increased production of small extracellular vesicles as a means of exporting cisplatin from the cell. This helps to prevent cisplatin-induced apoptosis in chemoresistant cells.