Resumen
Uveal melanoma (UM) is an eye cancer that will spread to other parts of the body in almost 50% of cases, most commonly to the liver. Regular liver scans can lead to early detection of UM metastases. Current guidelines recommend such liver surveillance in UM patients with a ?high risk? of metastasis but do not specify how this group is defined. Several different systems can estimate a patient?s risk of dying from metastatic UM. Our study compared the accuracy of different UM prognostic systems when used to target enrolment into surveillance programmes and suggests that some systems could relieve some patients from unnecessary scans and conserve resources. We found that using the Liverpool Uveal Melanoma Prognosticator Online III (LUMPOIII) could offer equal sensitivity and greater specificity than other systems. We suggest guidance for its use, even when genetic testing is not provided. This study provides important context for revising the clinical guidelines for stratification for surveillance in UM.