Resumen
The dramatic improvement in the prognosis of patients with advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) became possible thanks to the advent of EGFR-tyrosine kinase inhibitors (EGFR-TKIs). In a subgroup of EGFR mutations, known as uncommon (ucEGFRmuts) and rare, NSCLC-mutated patients show, most of the time, lower EGFR-TKIs sensitivity than most common mutations, making this a great clinical point of discussion. Here, we summarized recent data about EGFR exon 20 insertion-positive NSCLC patients and Phase 3 trials ongoing, with a specific focus on the PAPILLON study.