Resumen
Based on a real-world application in the semiconductor industry, this article models and discusses a hybrid flow shop problem with time dependencies and priority constraints. The analyzed problem considers a production where a large number of heterogeneous jobs are processed by a number of machines. The route that each job has to follow depends upon its type, and, in addition, some machines require that a number of jobs are combined in batches before starting their processing. The hybrid flow model is also subject to a global priority rule and a ?same setup? rule. The primary goal of this study was to find a solution set (permutation of jobs) that minimizes the production makespan. While simulation models are frequently employed to model these time-dependent flow shop systems, an optimization component is needed in order to generate high-quality solution sets. In this study, a novel algorithm is proposed to deal with the complexity of the underlying system. Our algorithm combines biased-randomization techniques with a discrete-event heuristic, which allows us to model dependencies caused by batching and different paths of jobs efficiently in a near-natural way. As shown in a series of numerical experiments, the proposed simulation-optimization algorithm can find solutions that significantly outperform those provided by employing state-of-the-art simulation software.