Resumen
During the last several years, gastric cancer has been extensively studied on the molecular level and distinct molecular subtypes have been defined accordingly. Here, we review the current data on targeted treatment approaches for advanced or metastatic gastric cancer based on molecular alterations or immunological features, ranging from clinically approved treatment strategies to more innovative concepts which are currently in preclinical or clinical development. Information on the translational context and methodology is also provided, holding promise for the further improved development of personalized treatment strategies in the future.