Resumen
Acute Promyelocytic Leukemia (APL) was the most aggressive form of leukemia, historically associated with massive and rapid mortality. However, empirical clinical advancements and in-depth mechanistic exploration have now transformed APL into the most curable form of leukemia, culminating with the ATRA/ATO combination, which cures up to 98% APL patients. This review recapitulates a three-decade journey which led to the development of this groundbreaking treatment, through several paradigm shifts to explain its scientific underpinnings.