Resumen
Liver metastases are a major cause of colorectal cancer mortality. To combat this, chemotherapy is widely used but generally does not result in long-term survival and causes serious side effects in many patients. We tested if a new polymeric chemotherapy, CF10, was more effective than the current drug, 5-FU, in a rat model of liver metastatic disease. Our studies proved that CF10 was better tolerated in rats than 5-FU, was more potent at decreasing the viability of rat colon cancer cells, and was significantly more effective than 5-FU at inhibiting cancer progression in a rat model of liver metastasis when administered at an equivalent dose. Based on these studies, we propose advancing CF10 into clinical trials and testing it for improved activity in human patients with colorectal liver metastases.