Resumen
Immune checkpoint inhibitors (ICIs) can cause granulomatous and sarcoid-like lesions (GSLs) in several organs, and limited data existing that adequately inform the incidence and severity. This study examined GSL incidence in patients with high-risk melanoma treated with CTLA4 or PD1 blocking adjuvant therapy in two randomized clinical trials, the ECOG-ACRIN E1609 and SWOG S1404. The investigation identified 11 GSL cases among 2878 patients treated with ICIs or high-dose IFNa-2b. Grade III events were dominantly reported. Lung, mediastinal lymph nodes, skin, subcutaneous tissue, and eye were implicated in the reported GSLs. In addition, 62 literature reports were summarized. In conclusion, GSLs following anti-CTLA4 or anti-PD1 adjuvant treatment were uncommonly reported.